The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
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DOI：
10.1007/s12015-010-9208-4
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发表时间：
2011-06-01
影响因子：
4.8
通讯作者：
Allan, Alison L.
中科院分区：
文献类型：
--
作者：
Ma, Irene;Allan, Alison L.
正常干细胞和癌症干细胞（CSC）具有相似的特性，都具有自我更新和分化成多种细胞类型的能力。在正常干细胞和癌症干细胞领域，都非常需要一种通用标记物，能够有效识别和分离这些稀有细胞群，以便表征它们并将这些信息用于研究和治疗目的。目前，乙醛脱氢酶 (ALDH) 超家族的某些同工酶似乎能够充当正常干细胞和癌症干细胞的标记物。 ALDH已被确定为保护正常造血干细胞的重要酶，目前也广泛用作鉴定和分离各类正常干细胞和CSC的标记物。此外，新出现的证据表明，ALDH1 不仅是干细胞的标记物，还可能发挥与自我保护、分化和扩增相关的重要功能作用。这篇综合综述讨论了 ALDH 在正常干细胞和 CSC 中发挥的作用，重点关注 ALDH1 和 ALDH3A1。还将讨论细胞类型之间功能主题的差异以及治疗应用的未来前景。
Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have the capacity to self-renew and differentiate into multiple cell types. In both the normal stem cell and cancer stem cell fields, there has been a great need for a universal marker that can effectively identify and isolate these rare populations of cells in order to characterize them and use this information for research and therapeutic purposes. Currently, it would appear that certain isoenzymes of the aldehyde dehydrogenase (ALDH) superfamily may be able to fulfill this role as a marker for both normal and cancer stem cells. ALDH has been identified as an important enzyme in the protection of normal hematopoietic stem cells, and is now also widely used as a marker to identify and isolate various types of normal stem cells and CSCs. In addition, emerging evidence suggests that ALDH1 is not only a marker for stem cells, but may also play important functional roles related to self-protection, differentiation, and expansion. This comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1. Discrepancies in the functional themes between cell types and future perspectives for therapeutic applications will also be discussed.