Quantitative relationship between anteriorization of alpha oscillations and level of general anesthesia
Quantitative relationship between anteriorization of alpha oscillations and level of general anesthesia
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DOI：
10.1007/s10877-022-00932-z
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发表时间：
2022-11-01
影响因子：
2.2
通讯作者：
Yamada，Yoshitsugu
中科院分区：
文献类型：
--
作者：
Azuma，Seiichi;Asamoto，Masaaki;Yamada，Yoshitsugu
全麻引起的典型脑电图变化是枕部α振荡的前麻醉消失，随后是额部α振荡的发展。研究这种特定的脑电图变化与麻醉水平之间的定量关系具有学术和临床意义。我们量化了麻醉程度，并研究了其与麻醉水平的详细关系。我们收集了50例手术患者从麻醉诱导前到唤醒后的21个电极EEG数据和双谱指数（BIS）值。对于具有1-s偏移的10.24秒窗口的每个历元，我们计算额α功率，枕α功率及其差异，以量化前化。我们计算了这些值与BIS值之间的Spearman等级相关系数。我们使用局部加权回归来估计，，，，，和每个BIS值。分析了36例患者，其中女性26例，男性10例，年龄24-85岁。Spearman秩相关系数与BIS值之间的Fisher变换均值的95%置信区间分别为[- 0.68,- 0.26]、[0.02,0.62]和[- 1.11,- 0.91]。inand与BIS值的变化随麻醉药物类型的不同呈现出不同的模式，而inand与BIS值的变化在较小的个体差异下更为一致。通过额叶和枕叶α功率的差异来量化的前化，与全身麻醉一起不断发展。量化麻醉前处理可以提供麻醉水平的客观指标。
A typical electroencephalogram (EEG) change induced by general anesthesia is anteriorization—disappearance of occipital alpha oscillations followed by the development of frontal alpha oscillations. Investigating the quantitative relationship between such a specific EEG change and the level of anesthesia has academic and clinical importance. We quantified the degree of anteriorization and investigated its detailed relationship with the level of anesthesia. We acquired 21-electrode EEG data and bispectral index (BIS) values of 50 patients undergoing surgery from before anesthesia induction until after patient arousal. For each epoch of a 10.24-s window with 1-s offsets, we calculated frontal alpha power, occipital alpha power, and their differenceto quantify anteriorization. We calculated Spearman’s rank correlation coefficients between these values and the BIS value. We used locally weighted regression to estimate,,,,, andat each BIS value. Thirty-six patients (26 females and 10 males aged 24–85 years) were analyzed. The 95% confidence intervals for the mean of Fisher transformations of Spearman’s rank correlation coefficients between,, andand BIS value were [− 0.68, − 0.26], [0.02, 0.62], and [− 1.11, − 0.91], respectively. The change inandwith BIS value showed different patterns by the type of anesthetic agent, whereas that inwas more consistent with smaller individual variance. Anteriorization, quantified by the difference between frontal and occipital alpha powers, continuously developed in conjunction with general anesthesia. Quantifying anteriorization may provide an objective indicator of the level of anesthesia.