Human NK cell education by inhibitory receptors for MHC class I
Human NK cell education by inhibitory receptors for MHC class I
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DOI：
10.1016/j.immuni.2006.06.013
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发表时间：
2006-08-01
期刊：
影响因子：
32.4
通讯作者：
Vivier, Eric
中科院分区：
文献类型：
--
作者：
Anfossi, Nicolas;Andre, Pascale;Vivier, Eric
自然杀伤(NK)细胞识别自身MHC I类分子的缺失，作为区分正常细胞和处于困境中的细胞的一种方法。在人类中，这种“失去自我”的识别是由抑制性受体(如KIR)确保的，KIR在与其MHC I类配体相互作用时抑制NK细胞的激活。我们在这里表明，NK细胞缺乏对自身MHC I类分子的抑制性KIR，存在于人外周血中。这些细胞具有成熟的NK细胞表型，但对各种刺激反应迟钝，包括MHC I类缺陷的靶细胞。这种反应与NK细胞不同，NK细胞表达针对自身MHC 1类的单一抑制性KIR，当暴露于相同的刺激时，NK细胞具有功能活性。这些结果表明KIR-MHC I类相互作用参与了NK细胞效应器能力的校准，表明它在随后的“缺失自我”识别中发挥作用。
Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate normal cells from cells in distress. In humans, this "missing self" recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon interaction with their MHC class I ligands. We show here that NK cells lacking inhibitory KIR for self MHC class I molecules are present in human peripheral blood. These cells harbor a mature NK cell phenotype but are hyporesponsive to various stimuli, including MHC class I-deficient target cells. This response is in contrast to NK cells that express a single inhibitory KIR specific for self MHC class 1, which are functionally competent when exposed to the same stimuli. These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent "missing self" recognition.