Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability.
Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability.
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纯化的细胞源性趋化因子诱导关节炎：趋化性和血管通透性的作用。
DOI：
10.1172/jci108674
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
B. Mandell
中科院分区：
文献类型：
--
作者：
I. Spilberg;D. Rosenberg;B. Mandell
将尿酸钠诱导的趋化因子注射到兔关节腔中，可引起急性炎症反应，类似于尿酸钠晶体引起的急性炎症反应。通过观察关节腔内125i -白蛋白的出现，该因子诱导的白细胞积累并没有伴随着血管通透性的可测量的增加。当组胺注射到关节时，血管通透性明显增加，但白细胞没有高于对照水平。上述结果表明，细胞衍生因子是尿酸钠晶体引起的急性炎症中细胞积聚的主要原因。
The injection of monosidium urate-induced chemotactic factor into the joint cavities of rabbits induces an acute inflammatory response that resembles the one produced by monosodium urate crystals. The leukocyte accumulation induced by the factor was not accompanied by a measurable increase in vascular permeability as measured by appearance of 125I-albumin in the joint cavity. When histamine was injected into the joints, a marked increase in vascular permeability but no leukocytosis above control levels was observed. The above results suggest that the cell-derived factor is primarily responsible for the accumulation of cells seen in the acute inflammation induced by monosodium urate crystals.