Familial Aggregation of Age-Related Hearing Loss in an Epidemiological Study of Older Adults
Familial Aggregation of Age-Related Hearing Loss in an Epidemiological Study of Older Adults
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DOI：
10.1044/1059-0889(2009/08-0035
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发表时间：
2009-12-01
影响因子：
1.8
通讯作者：
Cruickshanks, Karen J.
中科院分区：
文献类型：
--
作者：
Raynor, Laura A.;Pankow, James S.;Cruickshanks, Karen J.
目的：方法：对老年性耳聋患者进行听力测定，采用听力损失流行病学研究（EHLS）的3个波进行评估。使用了最近一次听力检查的测量结果，当时受试者（EHLS研究的3，510名参与者）年龄在48岁至100岁之间。采用最大似然法对376个家系的973对生物学亲属对进行了遗传度估计。家族聚集性也进行了评估，从373 sibishims.Results的594兄弟姐妹对的四项相关，比值比，和lambda统计：老年性耳聋的患病率符合以前的研究，随着年龄和男性的增加。根据年龄、性别、教育水平和暴露于工作噪音调整的老年性耳聋的遗传度估计值超过50%，受影响亲属的兄弟姐妹的风险高出30%。按性别分层时，估计的家庭聚集在女性高于男性Conclusions：有证据表明，遗传因素有助于年龄相关性听力损失，在这个以人口为基础的样本。女性的家庭聚集性比男性更强。
Purpose: To estimate the genetic contributions to presbycusis.Method: Presbycusis was assessed by audiometric measurements at 3 waves of the population-based Epidemiology of Hearing Loss Study (EHLS). Measurements from the most recent hearing examination were used, at which time the subjects (3,510 participants from the EHLS study) were between 48 and 100 years of age. Heritability of presbycusis was estimated using maximum likelihood methods in 973 biological relative pairs from 376 families. Familial aggregation was also evaluated by tetrachoric correlations, odds ratios, and lambda statistics in 594 sibling pairs from 373 sibships.Results: The prevalence of presbycusis conformed to previous research, increasing with age and male sex. Heritability estimates for presbycusis adjusted for age, sex, education level, and exposure to work noise exceeded 50%, and siblings of an affected relative were at 30% higher risk. When stratified by sex, estimates of familial aggregation were higher in women than men.Conclusions: There is evidence that genetic factors contribute to age-related hearing loss in this population-based sample. The familial aggregation is stronger in women than in men.