Novel phenotype issues raised in cross-national epidemiological research on drug dependence
Novel phenotype issues raised in cross-national epidemiological research on drug dependence
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DOI：
10.1111/j.1749-6632.2009.05419.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Anthony, James C. (Jim)
中科院分区：
文献类型：
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作者：
Anthony, James C. (Jim)
基于美国诊断和统计手册（DSM）的阶段转换模型通常应用于与大麻，可卡因和其他国际管制药物（IRD）相关的药物依赖综合征的流行病学和遗传学研究。DSM阶段转换模型的困难在旨在提供真正全球视角的跨国研究中浮出水面，例如世界心理健康调查联盟的工作。替代的更简单的依赖性相关表型是可能的，包括用于临床特征合并成连贯综合征之前的步骤的群体水平计数过程模型（例如，零膨胀泊松[ZIP]回归）。选定的研究结果进行审查，基于ZIP建模的酒精，烟草，和IRD计数过程中，与插图，可能会刺激新的研究遗传易感性性状。为此目的，可以随时修改年度全国药物使用和健康调查（NSDUH），沿着真正匿名的研究方法，可以帮助使NSDUH类型的跨国流行病学调查在随后的全基因组关联（GWAS）研究和GWAS后研究的背景下更有用。
Stage-transition models based on the American Diagnostic and Statistical Manual (DSM) generally are applied in epidemiology and genetics research on drug dependence syndromes associated with cannabis, cocaine, and other internationally regulated drugs (IRDs). Difficulties with DSM stage-transition models have surfaced during cross-national research intended to provide a truly global perspective, such as the work of the World Mental Health Surveys Consortium. Alternative simpler dependence-related phenotypes are possible, including population-level count process models for steps early and before coalescence of clinical features into a coherent syndrome (e.g., zero-inflated Poisson [ZIP] regression). Selected findings are reviewed, based on ZIP modeling of alcohol, tobacco, and IRD count processes, with an illustration that may stimulate new research on genetic susceptibility traits. The annual National Surveys on Drug Use and Health (NSDUH) can be readily modified for this purpose, along the lines of a truly anonymous research approach that can help make NSDUH-type cross-national epidemiological surveys more useful in the context of subsequent genomewide association (GWAS) research and post-GWAS investigations with a truly global health perspective.