Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
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DOI：
10.1523/jneurosci.22-18-07840.2002
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发表时间：
2002-09
期刊：
影响因子：
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通讯作者：
D. Francis;J. Diorio;P. Plotsky;M. Meaney
中科院分区：
文献类型：
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作者：
D. Francis;J. Diorio;P. Plotsky;M. Meaney
产后母亲分离会增加下丘脑促肾上腺皮质激素释放因子（CRF）基因表达以及下丘脑-垂体-肾上腺（HPA）和对压力的行为反应。我们在此报告，青春期前后的环境富集完全逆转了母体分离对 HPA 和应激行为反应的影响，而对 CRF mRNA 表达没有影响。我们得出的结论是，环境丰富化通过补偿而不是逆转早年逆境的神经影响，导致母性分离影响的功能性逆转。
Postnatal maternal separation increases hypothalamic corticotropin-releasing factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and behavioral responses to stress. We report here that environmental enrichment during the peripubertal period completely reverses the effects of maternal separation on both HPA and behavioral responses to stress, with no effect on CRF mRNA expression. We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity.