Self-complementary hydrogen-bond interactions of guanosine: a hub for constructing supra-amphiphilic polymers with controlled molecular structure and aggregate morphology.
Self-complementary hydrogen-bond interactions of guanosine: a hub for constructing supra-amphiphilic polymers with controlled molecular structure and aggregate morphology.
复制标题
DOI：
10.1039/c8sm02172d
复制
发表时间：
2018
期刊：
影响因子：
3.4
通讯作者：
Qian Xiao;Fei Song;Wu-Cheng Nie;Xiu-li Wang;Yu-Zhong Wang
中科院分区：
文献类型：
--
作者：
Qian Xiao;Fei Song;Wu-Cheng Nie;Xiu-li Wang;Yu-Zhong Wang
通过亲水性嵌段聚N-异丙基丙烯酰胺和疏水性嵌段聚ε-己内酯之间的鸟苷基团的自互补氢键作用，构建了一种分子结构可控的超两亲聚合物（SAP）。通过简单地改变鸟苷封端的亲水性和疏水性嵌段的混合比例，构建了一系列具有定制纳米结构的SAP，这些SAP可以在溶液中进一步自组装成不同的纳米聚集体，包括球体、囊泡和大囊泡胶束。亲水性嵌段的热诱导相变诱导纳米颗粒在加热时融合和聚集成不规则颗粒，其在冷却后进一步转化为大的复合囊泡。
A supra-amphiphilic polymer (SAP) with controlled molecular structures is constructed, in this work, via self-complementary hydrogen bonding of guanosine groups between a hydrophilic block, poly(N-isopropylacrylamide), and a hydrophobic block, poly(ε-caprolactone). By simply changing the mixing ratio of the guanosine-capped hydrophilic and hydrophobic blocks, a series of SAPs with tailored nanostructures are constructed, which can further self-assemble into different nano-aggregates in solution, including spheres, vesicles and large vesicle micelles. The thermo-induced phase transition of the hydrophilic block induces the fusion and aggregation of the nanoparticles into irregular particles upon heating, which further transform to large compound vesicles after cooling.