Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development
Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development
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DOI：
10.1016/s0925-4773(02)00282-4
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发表时间：
2002-10-01
影响因子：
2.6
通讯作者：
Theil, T
中科院分区：
文献类型：
--
作者：
Vacalla, CMH;Theil, T
锌指转录因子Castor在果蝇的神经发生过程中起着关键作用。在这里，我们报告的表达模式的小鼠蓖麻相关基因（Cst）在胚胎发生。Cst表达首先在发育中的心脏中在E8.0检测到，其中其表达在整个发育过程中保持。到E8.5，Cst表达开始于后脑的外侧神经褶皱，并向前和向后延伸，最终覆盖从峡部到其尾端的背侧神经管。从E9.5开始，Cst转录本也可以在背内侧端脑中检测到。在后脑，Cst表达仅限于三叉神经运动神经元和迁移面鳃神经元。在周围神经系统中，Cst在颅神经节和背根神经节中表达。在发育中的眼睛和鼻基板中也观察到Cst表达。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The zinc finger transcription factor Castor plays a pivotal role during neurogenesis in the fruit fly Drosophila melanogaster. Here, we report the expression pattern of a murine Castor related gene (Cst) during embryogenesis. Cst expression is first detected at E8.0 in the developing heart where its expression is maintained throughout development. By E8.5, Cst expression starts in the lateral neural folds of the hindbrain and extends anteriorly and posteriorly to eventually cover the dorsal neural tube from the isthmus to its caudal end. From E9.5, Cst transcripts can also be detected in the dorsomedial telencephalon. In the hindbrain, Cst expression is confined to trigeminal motor neurons and to migrating facial branchiomotor neurons. In the peripheral nervous system, Cst is expressed in cranial and in dorsal root ganglia. Cst expression is also observed in the developing eye and in the nasal placode. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.