A Generalized Formulation of Dual Radiation Action1
A Generalized Formulation of Dual Radiation Action1
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DOI：
10.1667/rrav17.1
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发表时间：
1978-09
期刊：
影响因子：
--
通讯作者：
A. Kellerer;H. Rossi
中科院分区：
文献类型：
--
作者：
A. Kellerer;H. Rossi
双重辐射作用是一个过程，其中细胞损伤是由电离辐射产生的分子改变的亚损伤对相互作用的结果。这一过程以前的公式采用了一些简化的假设，限制了理论分析的准确性和应用范围。这里提出的配方消除了一些这些限制，通过引入三个功能，描述了细胞中的敏感材料的几何形状，能量沉积的图案的几何形状，以及作为其分离的函数的亚病变的相互作用概率。导出的关系是类似于先前获得的，在该病变的生产被发现取决于两个条款，这是成比例的第一和第二次权力的吸收剂量。然而，这些项的系数现在是根据更现实的处理方法推导出来的。
Dual radiation action is a process in which cellular lesions are produced as a result of the interaction of pairs of sublesions that are molecular alterations produced by ionizing radiation. Previous formulations of this process have employed a number of simplifying assumptions that limit the accuracy and the range of application of theoretical analysis. The formulation presented here removes some of these restrictions by introducing three functions that describe the geometry of the sensitive material in the cell, the geometry of the pattern of energy deposition, and the interaction probability of sublesions as a function of their separation. The relation derived is similar to that obtained previously, in that lesion production is found to depend on two terms that are proportional to the first and the second power of the absorbed dose. However, the coefficients of these terms are now derived on the basis of a more realistic treatment.