PDB NextGen Archive: Centralising Access to Integrated Annotations and Enriched Structural Information by the Worldwide Protein Data Bank
PDB NextGen Archive: Centralising Access to Integrated Annotations and Enriched Structural Information by the Worldwide Protein Data Bank
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PDB NextGen Archive：通过全球蛋白质数据库集中访问集成注释和丰富的结构信息
DOI：
10.1101/2023.10.24.563739
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Choudhary P
中科院分区：
文献类型：
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作者：
Choudhary P
蛋白质数据库（PDB）是公共领域实验确定的3D生物分子结构信息的全球知识库。PDB的归档性质提出了与更新或添加来自可信外部生物数据资源的关联注释有关的某些挑战。虽然每个Worldwide PDB（wwPDB）合作伙伴都尽最大努力提供最新的外部注释，但访问和集成来自不同wwPDB数据中心的信息可能是一个复杂的过程。为了解决这个问题，wwPDB已经建立了PDB下一代（或NextGen）档案，旨在集中和简化对wwPDB合作伙伴和可信外部来源的丰富结构注释的访问。目前，NextGen Archive提供了实验确定的蛋白质和UniProt氨基酸序列的3D结构之间的映射，Pfam，SCOP2和CATH数据库的结构域注释以及分子内连接信息。自发布以来，PDB NextGen Archive已经获得了超过350万次数据文件下载的大量用户参与，确保研究人员能够访问准确，最新和易于访问的结构注释。数据库URL：http://www.wwpdb.org/ftp/pdb-nextgen-archive-site
The Protein Data Bank (PDB) is the global repository for public-domain experimentally determined 3D biomolecular structural information. The archival nature of the PDB presents certain challenges pertaining to updating or adding associated annotations from trusted external biodata resources. While each Worldwide PDB (wwPDB) partner has made best efforts to provide up-to-date external annotations, accessing and integrating information from disparate wwPDB data centers can be an involved process. To address this issue, the wwPDB has established the PDB Next Generation (or NextGen) Archive, developed to centralize and streamline access to enriched structural annotations from wwPDB partners and trusted external sources. At present, the NextGen Archive provides mappings between experimentally determined 3D structures of proteins and UniProt amino acid sequences, domain annotations from Pfam, SCOP2 and CATH databases and intra-molecular connectivity information. Since launch, the PDB NextGen Archive has seen substantial user engagement with over 3.5 million data file downloads, ensuring researchers have access to accurate, up-to-date and easily accessible structural annotations.Database URL: http://www.wwpdb.org/ftp/pdb-nextgen-archive-site