High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease
High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease
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DOI：
10.1016/j.jns.2008.08.029
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发表时间：
2009-01-15
影响因子：
4.4
通讯作者：
Heiss, W. D.
中科院分区：
文献类型：
--
作者：
Eggers, C.;Hilker, R.;Heiss, W. D.
高分辨率正电子发射断层扫描（PET）与新开发的HRRT扫描仪（Siemens/CTI）能可靠地定量18-氟脱氧葡萄糖（FDG）摄取作为参与帕金森病（PD）病理生理学的皮质下小核团神经元活动的标记物。10名早期PD患者和9名健康志愿者的细胞核。将PET数据与磁共振图像配准，并采用三维感兴趣体积（VOI）方法进行分析。在整体脑活动正常化后，PD患者双侧BG输出核（苍白球、黑质）和单侧尾状核和壳核的nCMRG 1c显著高于对照。丘脑底核、杏仁体和红核的代谢活动正常。这些第一批证据，活体帕金森病患者的HRCT PET数据扩展了BG中异常网络活动的先前脑成像结果，并证实了早期PD患者的输出核和纹状体过度激活。(C)2008 Elsevier B. V.保留所有权利。
High resolution positron emission tomography (PET) with the newly developed HRRT scanner (Siemens/CTI) permits the reliable quantification of 18- Fluorodeoxyglucose (FDG) uptake as a marker of neuronal activity in Small subcortical nuclei which are involved in the pathophysiology of Parkinson's disease (PD).We investigated the normalized cerebral metabolic rates of glucose (nCMRGlc) with HRRT PET in basal ganglia (BG) nuclei of 10 early-stage PD patients and in 9 healthy volunteers. PET data were co-registered to magnetic resonance images and analyzed in a three-dimensional volume-of-interest (VOI) approach. After normalization for global brain activity, PD patients showed a significantly higher nCMRGlc than controls bilaterally in the BG Output nuclei (pallidum, substantia nigra) and unilateral in the caudate and putamen. The metabolic activity of the nucleus the subthalamic nucleus, the corpus amygdaloideum and the red nucleus Was normal. These first accumbens, HRRT PET data in living parkinsonian humans extend previous brain imaging findings of abnormal network activity in the BG and confirm output nuclei and striatal overactivation also in early stage PD patients. (C) 2008 Elsevier B.V. All rights reserved.