Synthesis, characterization and cell imaging of a new polythiophene derivative
Synthesis, characterization and cell imaging of a new polythiophene derivative
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新型聚噻吩衍生物的合成、表征和细胞成像
DOI：
10.1016/j.dyepig.2018.05.070
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发表时间：
2018
影响因子：
4.5
通讯作者：
Yan Luke
中科院分区：
文献类型：
--
作者：
Wang Fengyan;Wei Junji;Xia Huiyun;Yan Ni;Song Jiale;Zhang Xiao;Gao Lining;Song Lifang;Yan Luke
荧光材料在生物成像领域起着至关重要的作用。虽然已经开发了许多荧光材料，但仍然迫切需要具有低细胞毒性和良好光稳定性的新荧光材料。本文设计并合成了一种新型聚噻吩衍生物PT-HMDA。PT-HMDA具有良好的水溶性、优异的物理化学性质、低细胞毒性和溶酶体特异性细胞定位。因此，它可能是一个有前途的和有指导意义的溶酶体特异性细胞成像材料的橙子荧光发射。
Fluorescent materials plays an essential role in the biological imaging field. Although numerous fluorescent materials have already been developed, new fluorescent materials with low cytotoxicity and good photostability are still urgently needed. In this work, a new polythiophene derivative PT-HMDA was designed and synthesized. PT-HMDA exhibits well water solubility, excellent photophysical properties, low cytotoxicity, and lysosome-specific cellular location. Thus, it could be a promising and instructive lysosome-specific cell imaging material with orange fluorescence emission.