Intra-oral gingival massage activates human cerebral prefrontal cortex and enhances cognitive performance
Intra-oral gingival massage activates human cerebral prefrontal cortex and enhances cognitive performance
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DOI：
10.1002/osi2.1175
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发表时间：
2023-02-13
影响因子：
0.5
通讯作者：
Okura，Yoshifumi
中科院分区：
文献类型：
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作者：
Rikimaru，Tetsuya;Okura，Yoshifumi
目的口腔护理与生活质量的提高和日常生活中认知能力的改变有关。已经研究了三叉神经刺激口腔护理方法（例如刷牙和口腔内冷刺激）与大脑激活的关系。本研究旨在阐明口腔内牙龈按摩对大脑前额皮质（PFC）区域激活和认知能力变化的影响。方法共有18名男性参与了这项研究。近红外光谱用于获取脑血红蛋白浓度的数据。使用在有或没有口内牙龈按摩刺激的情况下进行的 Stroop 认知测试来确定认知功能。结果与模仿牙龈按摩运动的参与者（对照组）相比，进行口内牙龈按摩的参与者的大脑 PFC 区域（包括左背外侧 PFC（DL-PFC）区域）的血流量显着增加（根据 Wilcoxon 符号等级法，p= 0.0104）。此外，牙龈按摩与认知能力的提高显着相关（通过 Wilcoxon 符号排序法，p< 0.0001），与左侧 DL-PFC 区域激活的增强相一致（通过 Fisher 精确概率检验，p= 0.039）。 结论 口内牙龈按摩激活了与认知能力增强相关的大脑 PFC 区域，表明牙龈按摩可能有助于改善认知能力。
AimOral care is associated with improved quality of life and changing cognitive performance in daily life. The association of trigeminal nerve‐stimulatory oral care methods, such as tooth brushing and intra‐oral cold stimuli, with cerebral activation has been studied. This study aimed to elucidate the effects of intra‐oral gingival massage on the cerebral prefrontal cortex (PFC) region activation and the changes in cognitive performance.MethodsA total of 18 men participated in this study. Near‐infrared spectroscopy was used to acquire data on the cerebral hemoglobin concentrations. Cognitive function was determined using the Stroop cognitive test performed with and without intra‐oral gingival massage stimulus.ResultsParticipants who performed intra‐oral gingival massage showed significantly increased blood flow in the cerebral PFC region, including the left dorsolateral PFC (DL‐PFC) region, compared with those who mimicked the movements of the gingival massage (control group) (p= 0.0104 by Wilcoxon signed rank method). Furthermore, gingival massage showed a significant association with increased cognitive performance (p< 0.0001 by Wilcoxon signed rank method) that coincided with the enhanced left DL‐PFC region activation (p= 0.039 by Fisher's exact probability test).ConclusionIntra‐oral gingival massage activated the cerebral PFC regions correlating with enhanced cognitive performance, suggesting that gingival massage may help improve cognitive performance.