THE SV40 ENHANCER CONTAINS 2 DISTINCT LEVELS OF ORGANIZATION
THE SV40 ENHANCER CONTAINS 2 DISTINCT LEVELS OF ORGANIZATION
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DOI：
10.1038/333040a0
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发表时间：
1988-05-05
期刊：
影响因子：
64.8
通讯作者：
HERR, W
中科院分区：
文献类型：
--
作者：
ONDEK, B;GLOSS, L;HERR, W
SV40 转录增强子由独立的 15 至 20 个碱基对 (bp) 长的增强子元件组成，这些增强子元件彼此协作或自身重复以增强转录。这些元件是二分的，由称为增强子的亚基组成，可以复制或互换以创建新的增强子元件。增强元件与增强元件不同，因为它们对间距的变化非常敏感。因此，这个原型增强器包含两个不同的组织级别，每个级别都需要冗余才能有效。
The SV40 transcriptional enhancer is composed of separate 15 to 20 base-pair-(bp)-long enhancer elements that cooperate with one another or duplicates of themselves to enhance transcription. These elements are bipartite, being composed of subunits, called enhansons, that can be duplicated or interchanged to create new enhancer elements. Enhansons differ from the enhancer elements because they are very sensitive to changes in spacing. This prototypic enhancer, therefore, contains two distinct levels of organization, each of which requires redundancy to be effective.