INTERLEUKIN-10 IN AMNIOTIC-FLUID AT MIDTRIMESTER - IMMUNE ACTIVATION AND SUPPRESSION IN RELATION TO FETAL GROWTH
INTERLEUKIN-10 IN AMNIOTIC-FLUID AT MIDTRIMESTER - IMMUNE ACTIVATION AND SUPPRESSION IN RELATION TO FETAL GROWTH
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DOI：
10.1016/s0002-9378(94)70077-x
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发表时间：
1994-07-01
影响因子：
9.8
通讯作者：
ABRAMS, JS
中科院分区：
文献类型：
--
作者：
HEYBORNE, KD;MCGREGOR, JA;ABRAMS, JS
目的：低出生体重仍然是围产期发病率和死亡率的主要原因，但对介导胎儿生长受损的机制知之甚少。为了进一步确定异常免疫激活和抑制在介导胎儿生长受损中的作用，我们测量了在遗传性羊水穿刺术获得的羊水样本中白细胞介素-10的水平，白细胞介素-10是一种以前未发现与妊娠相关的强效免疫抑制细胞因子。在一项采用酶联免疫测定的病例对照研究中，我们比较了从合适的妊娠中期孕妇获得的羊水中白细胞介素-10水平，结果：小于胎龄儿样本中的白细胞介素-10水平与对照样本中的水平（中位数< 40 pg/ml）相比升高（中位数78 pg/ml），p = 0.02。在小于胎龄妊娠中，升高的水平与未产相关，p = 0.003。结论：我们的数据支持异常免疫激活的作用，而不是免疫抑制不足，在介导胎儿生长受损。
OBJECTIVE: Low birth weight remains the leading cause of perinatal morbidity and mortality, but mechanisms mediating impaired fetal growth are poorly understood. To further define the role of abnormal immune activation and suppression in mediating impaired fetal growth, we measured levels of interleukin-10, a potent immunosuppressive cytokine not previously identified in association with pregnancy, in amniotic fluid samples obtained at genetic amniocentesis.STUDY DESIGN: In a case-control study with an enzyme-linked immunoassay we compared amniotic fluid levels of interleukin-10 in midtrimester samples obtained from appropriate-for-gestational age (n = 42) and small-for-gestational-age (n = 24) pregnancies.RESULTS: Interleukin-10 levels in small-for-gestational-age samples were elevated (median 78 pg/ml) compared with levels in control samples (median < 40 pg/ml), p = 0.02. In small-for-gestational-age pregnancies elevated levels were associated with nulliparity, p = 0.003.CONCLUSION: Our data support the role of abnormal immune activation, as opposed to inadequate immune suppression, in mediating impaired fetal growth.