FLAVONOID INTAKE AND LONG-TERM RISK OF CORONARY-HEART-DISEASE AND CANCER IN THE 7 COUNTRIES STUDY
FLAVONOID INTAKE AND LONG-TERM RISK OF CORONARY-HEART-DISEASE AND CANCER IN THE 7 COUNTRIES STUDY
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DOI：
10.1001/archinte.155.4.381
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发表时间：
1995-02-27
影响因子：
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通讯作者：
KATAN, MB
中科院分区：
文献类型：
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作者：
HERTOG, MGL;KROMHOUT, D;KATAN, MB
目的：确定黄酮类化合物摄入量是否能解释不同人群慢性疾病死亡率的差异。设计：跨文化相关性研究。背景/参与者：七国研究的16个队列，通过对代表该队列平均饮食的等效食物组合的类黄酮分析估计1960年左右基线时的类黄酮摄入量。主要结局指标：在25年的随访后，16个队列中冠心病、癌症（不同部位）和所有原因的死亡率。结果：抗氧化剂类黄酮的平均摄入量与冠心病死亡率呈负相关，并解释了16个队列中冠心病发病率差异的25%。在多变量分析中，饱和脂肪摄入量（73%；P= 0.0001）、类黄酮摄入量（8%；P= 0.01）和每个队列吸烟者百分比（9%；P= 0.03）共同解释了冠心病发病率差异的90%，而不包括酒精和抗氧化维生素的摄入量。黄酮类摄入与其他原因导致的死亡率没有独立关联。结论：平均类黄酮摄入量可能在一定程度上导致人群中冠心病死亡率的差异，但它似乎不是癌症死亡率的重要决定因素。
Objective: To determine whether flavonoid intake explains differences in mortality rates from chronic diseases between populations.Design: Cross-cultural correlation study. Setting/Participants:Sixteen cohorts of the Seven Countries Study in whom flavonoid intake at baseline around 1960 was estimated by flavonoid analysis of equivalent food composites that represented the average diet in the cohorts.Main Outcome Measures: Mortality from coronary heart disease, cancer (various sites), and all causes in the 16 cohorts after 25 years of follow-up.Results: Average intake of antioxidant flavonoids was inversely associated with mortality from coronary heart disease and explained about 25% of the variance in coronary heart disease rates in the 16 cohorts. In multivariate analysis, intake of saturated fat (73%; P=.0001), flavonoid intake (8%; P=.01), and percentage of smokers per cohort (9%; P=.03) explained together, independent of intake of alcohol and antioxidant vitamins, 90% of the variance in coronary heart disease rates. Flavonoid intake was not independently associated with mortality from other causes.Conclusions: Average flavonoid intake may partly contribute to differences in coronary heart disease mortality across populations, but it does not seem to be an important determinant of cancer mortality.