Prognostic impact of tumor-infiltrating lymphocytes in high grade serous ovarian cancer: a systematic review and meta-analysis.
Prognostic impact of tumor-infiltrating lymphocytes in high grade serous ovarian cancer: a systematic review and meta-analysis.
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DOI：
10.1177/1758835920967241
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发表时间：
2020
影响因子：
4.9
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Hao J;Yu H;Zhang T;An R;Xue Y
肿瘤浸润淋巴细胞（TIL）参与抗肿瘤免疫应答。TIL患者的预后与高级别浆液性卵巢癌（HGSOC）之间的关系仍然不清楚，一些研究报告了相互矛盾的结果。我们对电子数据库进行了广泛的文献检索，并检索了每种选定的TIL亚型的预后数据，包括CD 3+、CD 4+、CD 8+、CD 103+和PD-1+ TIL。应用固定效应模型推导这些标志物的合并风险比（HR）和95%置信区间（CI）。系统性综述过程产生了19项合格研究，包括6004例HGSOC患者。我们比较了TIL阳性和TIL阴性患者，多变量分析的合并HR显示，上皮内CD 8 + TIL与无进展生存率呈正相关。（PFS，HR 0.46，95% CI 0.25-0.67）和总生存期（OS，HR 0.90，95% CI 0.86-0.9）;间质CD 8 + TIL与OS呈正相关（HR 0.61，95% CI 0.36-0.87）。此外，单变量分析的合并HR表明，上皮内CD 3+、CD 4+、CD 8+和CD 103 + TIL与OS呈正相关（HR 0.58，95% CI 0.44-0.72; HR 0.37，95% CI 0.16-0.59; HR 0.51，95% CI 0.42-0.60和HR 0.59，95% CI 0.44-0.74）;基质CD 4+和CD 8 + TIL与OS显著相关（HR分别为0.63，95% CI 0.32-0.94和HR 0.78，95% CI 0.58-0.97）。然而，多变量分析的汇总HR显示PD-1+ TIL与HGSOC患者的OS无关（HR 0.97，95% CI 0.90-1.04）。该荟萃分析提供了CD 3+、CD 4+、CD 8+和CD 103 + TIL与HGSOC患者生存获益（OS和PFS）相关的证据。
Tumor-infiltrating lymphocytes (TILs) are involved in the antitumor immune response. The association between prognosis in patients with TILs and high-grade serous ovarian cancer (HGSOC) remains obscure, with some studies reporting conflicting results. We conducted an extensive literature search of electronic databases and retrieved prognostic data of each selected subtype of TILs, including CD3+, CD4+, CD8+, CD103+, and PD-1+ TILs. The fixed-effects model was applied to derive the pooled hazard ratio (HR) and 95% confidence interval (CI) of these markers. The systematic review process yielded 19 eligible studies comprising 6004 patients with HGSOC. We compared TIL-positive and TIL-negative patients, and the pooled HRs from the multivariate analysis revealed that intraepithelial CD8+ TILs were positively correlated with progression-free survival (PFS, HR 0.46, 95% CI 0.25–0.67) and overall survival (OS, HR 0.90, 95% CI 0.86–0.9); stromal CD8+ TILs were positively correlated with OS (HR 0.61, 95% CI 0.36–0.87). Furthermore, the pooled HRs from univariate analysis demonstrated that intraepithelial CD3+, CD4+, CD8+, and CD103+ TILs were positively associated with OS (HR 0.58, 95% CI 0.44–0.72; HR 0.37, 95% CI 0.16–0.59; HR 0.51, 95% CI 0.42–0.60, and HR 0.59, 95% CI 0.44–0.74, respectively); stromal CD4+ and CD8+ TILs were significantly associated with OS (HR 0.63, 95% CI 0.32–0.94 and HR 0.78, 95% CI 0.58–0.97, respectively). However, the pooled HR from the multivariate analysis revealed that PD-1+ TILs were not associated with the OS of patients with HGSOC (HR 0.97, 95% CI 0.90–1.04). This meta-analysis provided evidence of the association of CD3+, CD4+, CD8+, and CD103+ TILs with the survival benefits (OS and PFS) of patients with HGSOC.
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影响因子：
--
作者：
Darb-Esfahani S;Kunze CA;Kulbe H;Sehouli J;Wienert S;Lindner J;Budczies J;Bockmayr M;Dietel M;Denkert C;Braicu I;Jöhrens K
通讯作者：
Jöhrens K
影响因子：
11.5
作者：
Lo, Charlotte S.;Sanii, Sanaz;Nelson, Brad H.
通讯作者：
Nelson, Brad H.
DOI：
10.1038/nrc4019
发表时间：
2015-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Bowtell DD;Böhm S;Ahmed AA;Aspuria PJ;Bast RC Jr;Beral V;Berek JS;Birrer MJ;Blagden S;Bookman MA;Brenton JD;Chiappinelli KB;Martins FC;Coukos G;Drapkin R;Edmondson R;Fotopoulou C;Gabra H;Galon J;Gourley C;Heong V;Huntsman DG;Iwanicki M;Karlan BY;Kaye A;Lengyel E;Levine DA;Lu KH;McNeish IA;Menon U;Narod SA;Nelson BH;Nephew KP;Pharoah P;Powell DJ Jr;Ramos P;Romero IL;Scott CL;Sood AK;Stronach EA;Balkwill FR
通讯作者：
Balkwill FR
影响因子：
50.3
作者：
Anderson KG;Stromnes IM;Greenberg PD
通讯作者：
Greenberg PD
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG