Behavioral and histological effects of acrylamide in rainbow trout.
Behavioral and histological effects of acrylamide in rainbow trout.
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丙烯酰胺对虹鳟鱼的行为和组织学影响。
DOI：
10.1016/0041-008x(87)90095-0
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发表时间：
1987
影响因子：
3.8
通讯作者：
Lech,JJ
中科院分区：
文献类型：
--
作者：
Petersen,DW;Cooper,KR;Friedman,MA;Lech,JJ
采用组织学和行为学方法研究了丙烯酰胺对虹鳟鱼的神经毒性作用。鳟鱼暴露于0，12.5，或25毫克/升丙烯酰胺15天的游泳性能不受影响。暴露于50 mg/L丙烯酰胺相似时间段的动物的游泳性能受到该处理组中动物的发病率和死亡率的影响。中枢神经元、外周神经元或肌肉中不存在剂量相关的组织学病变，表明观察到的游泳能力缺陷是由于全身毒性反应所致。丙烯酰胺处理产生剂量相关的病变，在鳃和肝脏的虹鳟鱼。
A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.