Iatrogenic Wernicke's encephalopathy in allogeneic bone marrow transplantation: a study of eight cases
Iatrogenic Wernicke's encephalopathy in allogeneic bone marrow transplantation: a study of eight cases
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DOI：
10.1038/sj.bmt.1700892
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发表时间：
1997-09-01
影响因子：
4.8
通讯作者：
deMedeiros, CR
中科院分区：
文献类型：
--
作者：
BleggiTorres, LF;deMedeiros, BC;deMedeiros, CR
韦尼克脑病（WE）是一种神经精神疾病，通常由急性硫胺素缺乏引起，典型的包括精神状态改变、共济失调和眼肌麻痹三联征。它在酗酒者中最常见，但也有其他几种原因，包括全胃肠外营养（TPN）的使用。其中硫胺素缺乏症是由TPN给药期间缺乏维生素补充引起的。临床上，WE表现为严重的难治性代谢性酸中毒，之前有“乌藨子舌”，以及眼科和神经功能障碍。受影响最大的部位是脑室周围结构和丘脑，没有发现乳头体病变。
Wernicke's encephalopathy (WE) is a neuropsychiatric condition generally caused by acute thiamine deficiency and classically involves the triad of altered mentation, ataxia and ophthalmoplegia, It is most common among alcoholics, but several other causes have been identified, including total parenteral nutrition (TPN) use, We present eight cases of WE in patients undergoing allogeneic BMT, where thiamine deficiency was caused by a lack of vitamin supplementation during TPN administration. Clinically, WE presented as a severe refractory metabolic acidosis, preceded by 'raspberry tongue', and ophthalmologic and neurologic dysfunction. The sites most affected were the periventricular structures and the thalamus, and no mammilary bodies lesions were found.