The PAI-1 4G/5G gene polymorphism and ischemic stroke: an association study and meta-analysis.
The PAI-1 4G/5G gene polymorphism and ischemic stroke: an association study and meta-analysis.
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DOI：
10.1016/j.jstrokecerebrovasdis.2007.03.002
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发表时间：
2007-07-01
期刊：
影响因子：
--
通讯作者：
Levi, Christopher
中科院分区：
文献类型：
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作者：
Attia, John;Thakkinstian, Ammarin;Levi, Christopher
为探讨纤溶酶原激活物抑制物1（派-1）4G/5G多态性和组织型纤溶酶原激活物（t-PA）-7351 C/T多态性与缺血性脑卒中的相关性，我们对190例首次缺血性脑卒中住院患者和185例社区对照进行了病例对照研究。我们的研究结果并没有表明派-1或t-PA多态性与卒中风险之间存在任何关联。将我们的派-1结果添加到先前的荟萃分析研究中，表明该多态性与缺血性卒中之间存在强相关性（P = 0.0002），没有发表偏倚，但具有极高的异质性。有证据表明中风与派-1 4G/5G位点相关。强烈的异质性表明需要解决其他问题，包括与特定中风亚型的关联或与另一个致病等位基因的连锁不平衡（LD）。这些结果也是一个警示，即不同人群的LD结构可能会掩盖与致病基因座的关系，未来的荟萃分析需要超越简单的汇总估计。
To investigate whether the 4G/5G polymorphism of plasminogen activator inhibitor type 1 (PAI-1) and the -7351 C/T polymorphism of tissue-type plasminogen activator (t-PA) are associated with ischemic stroke, we conducted a case-control study of 190 hospital cases of first-ever ischemic stroke and 185 community-based controls. Our findings do not indicate any association between the PAI-1 or t-PA polymorphisms and risk of stroke. Adding our PAI-1 results to previous studies in a meta-analysis indicated a strong association between this polymorphism and ischemic stroke (P = .0002), with no publication bias but with extreme heterogeneity. There was evidence of stroke association with the PAI-1 4G/5G locus. Strong heterogeneity indicates the need to address other issues, including association with particular stroke subtypes or linkage disequilibrium (LD) with another causative allele. The results also sound a cautionary note that varying LD structure across populations may obscure the relationship with a causative locus, and that future meta-analyses need to look beyond a simple pooled estimate.