Heterogeneity identified at birth and blood pressure in adulthood.
Heterogeneity identified at birth and blood pressure in adulthood.
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出生时发现的异质性和成年后血压的异质性。
DOI：
10.1002/ajhb.22828
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Dirienzo,Gregory
中科院分区：
文献类型：
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作者：
Gage,TimothyB;Lee,FurrinaF;O'Neill,ErinK;Napierala,Jeff;Dirienzo,Gregory
ObjectiveIn the developmental programming literature, the association of birth weight and blood pressure later in life is modest at best. This article reexamines this issue using Covariate Density Defined mixture of regressions (CDDmr) to determine if a latent variable, based on birth weight, and known to influence infant mortality, provides a stronger indicator of developmental programming.MethodsCDDmr identifies two latent components in the birth weight distribution, generally interpreted in the infant mortality literature as “compromised” and “normal” fetal development. The data are taken from the 1958 British National Child Development Study.ResultsIn the 1958 cohort, the “compromised” component consists of about 10% of the birth weight distribution. Compared to “normal” births, the mean systolic blood pressure at age 45 of “compromised” births is 20.3 (females) and 26.4 (males) mm Hg higher than “normal” births. The relative risks of stage‐I‐II systolic hypertension (>140 mm Hg) of “compromised” births compared to “normal” births are 10.7 (females) and 4.2 (males). The relative risks of stage‐II systolic hypertension (>160 mm Hg) are considerably higher, 241.6 (females) and 74.3 (males). In general, the highest blood pressures are observed in “compromised” births with birth weights within the normal (about 3.0–3.5 kg) birth weight range. Results for diastolic blood pressure are similar.ConclusionsThese associations are much stronger than those identified using conventional methods. CDDmr is likely to be useful for studying the dynamics of developmental programming particularly in large cohort studies where birth weight is often the only indicator of programming available. Am. J. Hum. Biol. 28:545–554, 2016. © 2016 Wiley Periodicals, Inc.
