Neuron-glia interaction as a possible glue to translate the mind-brain gap: a novel multi-dimensional approach toward psychology and psychiatry.
Neuron-glia interaction as a possible glue to translate the mind-brain gap: a novel multi-dimensional approach toward psychology and psychiatry.
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DOI：
10.3389/fpsyt.2013.00139
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发表时间：
2013-10-21
影响因子：
4.7
通讯作者：
Kanba S
中科院分区：
文献类型：
--
作者：
Kato TA;Watabe M;Kanba S
神经元和突触长期以来一直是神经科学的主要焦点，因此精神疾病的病理生理学已在神经元学说中得到理解。然而，大脑中的大多数细胞不是神经元，而是神经胶质细胞，包括星形胶质细胞、少突胶质细胞和小胶质细胞。传统上，神经科学家认为神经胶质的功能只是为神经元提供物理支持和维护。因此，神经胶质细胞的这种有限作用长期以来一直被忽视。近年来，神经胶质细胞的功能逐渐被研究，越来越多的证据表明神经胶质细胞在各种脑功能中发挥着重要作用。挖掘神经胶质细胞的功能并进一步了解这些关键细胞以及神经元和神经胶质细胞之间的相互作用可能会为澄清许多未知方面（包括心脑间隙和意识与无意识关系）提供新的线索。我们简要回顾了该领域神经胶质细胞研究的现状，并结合动物研究、体外和体内神经元神经胶质细胞研究、各种人脑成像研究和心理测量评估等多种实验方法，提出了一种新颖的多维模型转化研究。
Neurons and synapses have long been the dominant focus of neuroscience, thus the pathophysiology of psychiatric disorders has come to be understood within the neuronal doctrine. However, the majority of cells in the brain are not neurons but glial cells including astrocytes, oligodendrocytes, and microglia. Traditionally, neuroscientists regarded glial functions as simply providing physical support and maintenance for neurons. Thus, in this limited role glia had been long ignored. Recently, glial functions have been gradually investigated, and increasing evidence has suggested that glial cells perform important roles in various brain functions. Digging up the glial functions and further understanding of these crucial cells, and the interaction between neurons and glia may shed new light on clarifying many unknown aspects including the mind-brain gap, and conscious-unconscious relationships. We briefly review the current situation of glial research in the field, and propose a novel translational research with a multi-dimensional model, combining various experimental approaches such as animal studies, in vitro & in vivo neuron-glia studies, a variety of human brain imaging investigations, and psychometric assessments.