Evolutionary divergence of trigeminal nerve somatotopy in amniotes
Evolutionary divergence of trigeminal nerve somatotopy in amniotes
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DOI：
10.1002/cne.23236
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发表时间：
2013-04-15
影响因子：
2.5
通讯作者：
Rijli, Filippo M.
中科院分区：
文献类型：
--
作者：
Rhinn, Muriel;Miyoshi, Kanako;Rijli, Filippo M.
三叉神经回路将来自面部的躯体感觉输入中继到中枢神经系统。在中央核团，神经元的空间排列再现了外周受体的物理分布，从而在发育过程中产生了躯体定位的面部地图。在小鼠中，眼、上颌和下颌三叉神经分支保持躯体位置分离，并在后脑靶核内产生空间组织的连接模式。为了探讨保护的躯体位置组织，我们比较了三叉神经组织在海龟，鸡，小鼠胚胎。我们发现，在龟，下颌和上颌神经节神经元的吻尾分离和三叉神经束的体貌特征与小鼠相似。相比之下，鸡下颌神经节神经元位于上颌神经元的吻侧，具有一些混合，支持先前的观察结果（Noden [1980]，J Comp Neurol 190：429444）。与小鼠和乌龟相比，这种组织导致三叉神经束内上颌和下颌支的相对位置倒置和较不精确的轴突分类。此外，使用Drg 11的龟和鸡直系同源物结合Hoxa 2表达和来自外周的轴突示踪，我们将鸡PrV核位置定位到菱形节1，证实了先前的研究（Marin和Puelles [1995]，Eur J Neurosci 7：17141738），并且与主要定位到菱形节23的小鼠PrV形成对比（Oury等人[2006]，Science 313：14081413）。因此，三叉神经节和神经组织的躯体解剖学仅部分地通过神经元进化而被保存，这可能与面部躯体感觉结构和形态的改变有关。神经学比较杂志13781394，2013. (c)2012 Wiley Periodicals，Inc.
The trigeminal circuit relays somatosensory input from the face into the central nervous system. In central nuclei, the spatial arrangement of neurons reproduces the physical distribution of peripheral receptors, thus generating a somatotopic facial map during development. In mice, the ophthalmic, maxillary, and mandibular trigeminal nerve branches maintain a somatotopic segregation and generate spatially organized patterns of connectivity within hindbrain target nuclei. To investigate conservation of somatotopic organization, we compared trigeminal nerve organization in turtle, chick, and mouse embryos. We found that, in the turtle, mandibular and maxillary ganglion neuron rostrocaudal segregation and trigeminal tract somatotopy are similar to mouse. In contrast, chick mandibular ganglion neurons are located rostrally to maxillary neurons, with some intermingling, supporting previous observations (Noden [1980], J Comp Neurol 190:429444). This organization results in an inversion of the relative positions and less precise axonal sorting of the maxillary and mandibular branches within the trigeminal tract, as compared to mouse and turtle. Moreover, using the turtle and chick orthologs of Drg11 in combination with Hoxa2 expression and axonal tracings from the periphery, we mapped the chick PrV nucleus position to rhombomere 1, confirming previous studies (Marin and Puelles [1995], Eur J Neurosci 7:17141738) and in contrast to mouse PrV, which mainly maps to rhombomere 23 (Oury et al. [2006], Science 313:14081413). Thus, somatotopy of trigeminal ganglion and nerve organization is only partially conserved through amniote evolution, possibly in relation to the modification of facial somatosensory structures and morphologies. J. Comp. Neurol. 13781394, 2013. (c) 2012 Wiley Periodicals, Inc.