Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography
Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography
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DOI：
10.1183/09031936.00041809
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发表时间：
2010-01-01
影响因子：
24.3
通讯作者：
Eastwood, P. R.
中科院分区：
文献类型：
--
作者：
Williamson, J. P.;Armstrong, J. J.;Eastwood, P. R.
由于光学畸变和测量深度的能力有限，气道尺寸难以在支气管镜下量化。解剖光学相干断层扫描（aOCT）是一种新的成像技术，可以克服这些限制。本研究评估了aOCT在假体、切除的猪和活体人气道中与现有技术的准确性。进行了三项比较研究：1)将10根塑料管的微米衍生面积与aoct衍生面积进行了比较；2)比较aoct获得的切除猪气道顺应性曲线与内镜技术获得的曲线；3)在4例麻醉患者的支气管镜检查期间，使用aOCT测量从气管到亚段支气管的气道尺寸，并与计算机断层扫描（CT）测量结果进行比较。在塑料管中的测量表明，acoct是准确可靠的。在猪气道中，aoct衍生的顺应性测量与内窥镜数据密切相关。在人体气道中，aOCT和CT测量的尺寸密切相关。Bland-Altman图显示，aOCT直径和面积测量值分别比CT测量值高7.6%和15.1%。使用aOCT进行气道测量是准确、可靠的，并且与现有的成像技术相比具有优势。使用aOCT与常规支气管镜检查可以实时测量气道尺寸，在需要气道口径知识的临床环境中可能有用。
Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways.Three comparative studies were performed: 1) micrometer-derived area measurements in 10 plastic tubes were compared with aOCT-derived area; 2) aOCT-derived airway compliance curves from excised pig airways were compared with curves derived using an endoscopic technique; and 3) airway dimensions from the trachea to subsegmental bronchi were measured using aOCT in four anaesthetised patients during bronchoscopy and compared with computed tomography (CT) measurements.Measurements in plastic tubes revealed aOCT to be accurate and reliable. In pig airways, aOCT-derived compliance measurements compared closely with endoscopic data. In human airways, dimensions measured with aOCT and CT correlated closely. Bland-Altman plots showed that aOCT diameter and area measurements were higher than CT measurements by 7.6% and 15.1%, respectively.Airway measurements using aOCT are accurate, reliable and compare favourably with existing imaging techniques. Using aOCT with conventional bronchoscopy allows real-time measurement of airway dimensions and could be useful clinically in settings where knowledge of airway calibre is required.