Trachoma
Trachoma
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DOI：
10.1016/s0140-6736(13)62182-0
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发表时间：
2014-12-13
期刊：
影响因子：
168.9
通讯作者：
Wright, Heathcote
中科院分区：
文献类型：
--
作者：
Taylor, Hugh R.;Burton, Matthew J.;Wright, Heathcote
沙眼是最常见的致盲传染病。儿童期沙眼衣原体反复感染可导致严重的结膜炎症、瘢痕形成，并在以后的生活中可能使内翻的睫毛失明（倒睫或睑内翻）。沙眼发生在卫生条件不佳的资源贫乏地区，面部不洁的儿童分享受感染的眼部分泌物。关于沙眼的流行病学和病理生理学已经有了很多了解。综合控制方案正在执行安全战略：倒睫手术、大量分发抗生素、促进面部清洁和改善环境。这一战略已在几个国家成功消除了沙眼，全球正在努力到2020年在全球范围内消除致盲性沙眼。
Trachoma is the most common infectious cause of blindness. Repeated episodes of infection with Chlamydia trachomatis in childhood lead to severe conjunctival inflammation, scarring, and potentially blinding inturned eyelashes (trichiasis or entropion) in later life. Trachoma occurs in resource-poor areas with inadequate hygiene, where children with unclean faces share infected ocular secretions. Much has been learnt about the epidemiology and pathophysiology of trachoma. Integrated control programmes are implementing the SAFE Strategy: surgery for trichiasis, mass distribution of antibiotics, promotion of facial cleanliness, and environmental improvement. This strategy has successfully eliminated trachoma in several countries and global efforts are underway to eliminate blinding trachoma worldwide by 2020.