Hepatocellular carcinoma: making sense of morphological heterogeneity, growth patterns, and subtypes.
Hepatocellular carcinoma: making sense of morphological heterogeneity, growth patterns, and subtypes.
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肝细胞癌：了解形态异质性、生长模式和亚型。
DOI：
10.1016/j.humpath.2020.12.009
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发表时间：
2021-06
期刊：
影响因子：
3.3
通讯作者：
Torbenson, Michael S.
中科院分区：
文献类型：
--
作者：
Torbenson, Michael S.
关键词：
肝细胞癌不是一组同质的肿瘤，而是具有多层异质性。这种异质性已被研究多年，目的是为患者提供个性化护理，并已导致通过形态学和/或分子方法确定许多肝细胞癌亚型。本文回顾了肝细胞癌内的总体和组织学异质性水平，重点是组织学发现，回顾了如何使用不同水平的组织学异质性作为构建形态学肝细胞癌亚型的基石。目前最好的做法，定义一个形态亚型的概述。然后，回顾了十三种不同肝细胞癌亚型的定义。对于这些亚型中的每一个，突出强调了有关其定义的未解决问题，包括对这些有问题的领域的建议。最后，提出了三点改进肝癌亚型研究的方法：1。使用系统的，严格的方法来定义肝细胞癌亚型（四点模型）; 2.一旦确定了亚型的定义，在研究中应该遵循它，因为这个共同点增强了在研究之间比较结果的能力; 3.当形态学和分子学结果用于协同和迭代研究设计时，亚型研究将更有效，其中一种方法的结果用于改进和锐化另一种方法的结果。这些和相关的努力，以更好地了解异质性肝细胞癌是最有前途的途径，改善病人的护理个性化的病人护理。
Hepatocellular carcinomas are not a homogenous group of tumors, but have multiple layers of heterogeneity. This heterogeneity has been studied for many years with the goal to individualize care for patients and has led to the identification of numerous hepatocellular carcinoma subtypes, defined by morphology and or molecular methods. This article reviews both gross and histological levels of heterogeneity within hepatocellular carcinoma, with a focus on histological findings, reviewing how different levels of histological heterogeneity are used as building blocks to construct morphological hepatocellular carcinoma subtypes. The current best-practice for defining a morphological subtype is outlined. Then, the definition for thirteen distinct hepatocellular carcinoma subtypes is reviewed. For each of these subtypes, unresolved issues regarding their definitions are highlighted, including recommendations for these problematic areas. Finally, three methods for improving the research on hepatocellular carcinoma subtypes are proposed: 1. Use a systemic, rigorous approach for defining hepatocellular carcinomas subtypes (four point model); 2. Once a definitions for a subtype is established, it should be followed in research studies, as this common denominator enhances the ability to compare results between studies; 3. Studies of subtypes will be more effective when morphological and molecular results are used in synergistic and iterative study designs where the results of one approach are used to refine and sharpen the results of the other. These and related efforts to better understand heterogeneity within hepatocellular carcinoma are the most promising avenue for improving patient care by individualizing patient care.
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影响因子：
4.6
作者：
Clayton, Erica F.;Malik, Saloni;Bonnel, Alexander;Mu, Yifei;Olthoff, Kim;Shaked, Abraham;Abt, Peter L.;Peterman, Heather;Reddy, K. Rajender;Ottmann, Shane;Furth, Emma E.;Levine, Matthew H.
通讯作者：
Levine, Matthew H.
影响因子：
13.5
作者：
Graham, Rondell P.;Lackner, Carolin;Torbenson, Michael S.
通讯作者：
Torbenson, Michael S.
影响因子：
5.6
作者：
Chan, Anthony W. H.;Tong, Joanna H. M.;To, Ka-Fai
通讯作者：
To, Ka-Fai
影响因子：
11.5
作者：
Calderaro, Julien;Meunier, Lea;Ziol, Marianne
通讯作者：
Ziol, Marianne
DOI：
10.1038/modpathol.2017.103
发表时间：
2018-01
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Graham RP;Yeh MM;Lam-Himlin D;Roberts LR;Terracciano L;Cruise MW;Greipp PT;Zreik RT;Jain D;Zaid N;Salaria SN;Jin L;Wang X;Rustin JG;Kerr SE;Sukov WR;Solomon DA;Kakar S;Waterhouse E;Gill RM;Ferrell L;Alves VA;Nart D;Yilmaz F;Roessler S;Longerich T;Schirmacher P;Torbenson MS
通讯作者：
Torbenson MS