The common ancestor at a nonneutral locus
The common ancestor at a nonneutral locus
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非中性位点的共同祖先
DOI：
10.1239/jap/1019737986
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发表时间：
2002
影响因子：
1
通讯作者：
P. Fearnhead
中科院分区：
文献类型：
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作者：
P. Fearnhead
我们考虑了一个具有双亲独立突变和两个选择类的非中性群体遗传学模型。我们从这个模型中计算了一组基因样本的共同祖先类型的平稳分布。任何祖先(包括任何样本中最近的共同祖先)的预期适应度被证明大于从群体中随机选择的基因的预期适应度。还分析了共同祖先的突变过程。我们的结果与扩散理论的结果有关，但比扩散理论的结果更一般。
We consider a nonneutral population genetics model with parent-independent mutations and two selective classes. We calculate the stationary distribution of the type of the common ancestor of a sample of genes from this model. The expected fitness of any ancestor (including the most recent common ancestor of any sample) is shown to be greater than the expected fitness of a randomly chosen gene from the population. The process of mutations to the common ancestor is also analysed. Our results are related to, but more general than, results obtained from diffusion theory.