Associations of noniodized salt and thyroid nodule among the Chinese population: a large cross-sectional study
Associations of noniodized salt and thyroid nodule among the Chinese population: a large cross-sectional study
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DOI：
10.3945/ajcn.112.054353
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发表时间：
2013-09-01
影响因子：
7.1
通讯作者：
Yu, Yunxian
中科院分区：
文献类型：
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作者：
Chen, Zexin;Xu, Weimin;Yu, Yunxian
背景资料：在过去的几年里，碘盐可能会增加甲状腺疾病的风险的争议在中国已经出现，在过去的几年里，目的：这项研究旨在探讨是否碘盐增加甲状腺结节的风险在中国人群中，设计：一个横断面研究，在中国杭州，在2010年进行。对9412名成人进行了碘盐摄入量、尿碘浓度（UIC）和甲状腺结节超声检查。结果：甲状腺结节的患病率男性为24.1%，女性为34.7%。食用非碘盐的成年人患甲状腺结节的风险增加（OR：1.36; 95%CI：1.01，1.83）。同样，与中度盐食欲相比，轻度盐食欲与所有成人（OR：1.19; 95% CI：1.03，1.37）和女性（OR：1.23; 95% CI：1.03，1.46）中甲状腺结节风险增加相关。此外，那些既不食用碘盐也不食用牛奶的人比那些既食用碘盐又食用牛奶的人有更高的甲状腺结节风险（OR：1.72; 95%CI：1.21，2.43）。此外，甲状腺结节的风险增加（OR：1.25; 95%CI：1.07，1.45）之间的混合样本和妇女低UIC。结论：这些研究结果表明，低碘摄入量可能会增加甲状腺结节的风险在中国人群中，特别是在妇女。因此，全民食盐加碘计划对于像杭州这样的中国沿海地区的居民来说是必不可少的。本试验在clinicaltrials.gov上注册为NCT 01838629。
Background: The controversy that iodized salt may increase the risk of thyroid disorders has arisen in China during the past several years.Objective: This study aimed to explore whether iodized salt increased the risk of thyroid nodule among a Chinese population.Design: A cross-sectional study was conducted in Hangzhou, China, in 2010. Iodized salt intake, urinary iodine concentration (UIC), and thyroid nodule (by ultrasonography) were measured in 9412 adults. The associations of iodized salt with thyroid nodule were evaluated by using multiple mixed logistic regression models.Results: The prevalence of thyroid nodule among men and women was 24.1% and 34.7%, respectively. Adults consuming noniodized salt had an increased risk of thyroid nodule (OR: 1.36; 95% CI: 1.01, 1.83). Similarly, compared with moderate salt appetite, mild salt appetite was associated with an increased risk of thyroid nodule among all adults (OR: 1.19; 95% CI: 1.03, 1.37) and among women (OR: 1.23; 95% CI: 1.03, 1.46). Furthermore, those who consumed neither iodized salt nor milk had a higher risk of thyroid nodule (OR: 1.72; 95% CI: 1.21, 2.43) than did those who consumed both iodized salt and milk. In addition, an increased risk of thyroid nodule (OR: 1.25; 95% CI: 1.07, 1.45) was observed among both pooled samples and women with low UIC.Conclusions: These findings indicate that low iodine intake may increase the risk of thyroid nodule in a Chinese population, particularly in women. Hence, the Universal Salt Iodization program may be indispensable for a coastal Chinese population such as that living in Hangzhou. This trial was registered at clinicaltrials.gov as NCT01838629.