Insulin-like growth factor-1 deficiency and metabolic syndrome.
Insulin-like growth factor-1 deficiency and metabolic syndrome.
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DOI：
10.1186/s12967-015-0762-z
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发表时间：
2016-01-06
影响因子：
7.4
通讯作者：
Castilla-Cortazar I
中科院分区：
文献类型：
--
作者：
Aguirre GA;De Ita JR;de la Garza RG;Castilla-Cortazar I
一致的证据关联IGF-1缺乏症和代谢综合征。在这篇综述中，我们将重点介绍IGF-1的代谢作用，代谢综合征的概念及其临床表现（血脂异常，胰岛素抵抗，血糖水平升高，肥胖和心血管疾病），讨论IGF-1替代治疗是否可能是这些患者的有益策略。在Medline中为Pubmed制定了检索计划，使用以下网格术语：IGF-1和"代谢、碳水化合物、脂质、蛋白质、氨基酸、代谢综合征、心血管疾病、糖尿病"（1963 - 2015年）。搜索包括动物和人类协议。本文就IGF-1在代谢中的相关作用及IGF-1缺乏在代谢综合征形成中的意义进行综述。多项研究（体外和体内）证明了IGF-1缺陷与脂质代谢失调、心血管疾病、糖尿病和糖尿病患者代谢谱改变之间的关联。基于现有的数据，我们提出IGF-1作为代谢综合征的病理生理学中的关键激素;由于其在碳水化合物和脂质代谢中的意义。以前的数据表明，IGF-1如何成为治疗这种全球性疾病的有效选择。必须区分的是，替代疗法应仅用于恢复生理水平，决不能超过生理范围。
Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients. The search plan was made in Medline for Pubmed with the following mesh terms: IGF-1 and “metabolism, carbohydrate, lipids, proteins, amino acids, metabolic syndrome, cardiovascular disease, diabetes” between the years 1963–2015. The search includes animal and human protocols. In this review we discuss the relevant actions of IGF-1 on metabolism and the implication of IGF-1 deficiency in the establishment of metabolic syndrome. Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients. Based on the available data we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome; due to its implications in the metabolism of carbohydrates and lipids. Previous data demonstrates how IGF-1 can be an effective option in the treatment of this worldwide increasing condition. It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges.