The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
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DOI：
10.1038/nchembio.1734
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发表时间：
2015-03-01
影响因子：
14.8
通讯作者：
Suessmuth, Roderich D.
中科院分区：
文献类型：
--
作者：
Cociancich, Stephane;Pesic, Alexander;Suessmuth, Roderich D.
Albicidin 是一种有效的 DNA 旋转酶抑制剂，由甘蔗致病菌 Xanthomonas albilineans 产生。在这里，我们报道了迄今为止未知的 albicidin 结构的阐明，揭示了一种主要由对氨基苯甲酸组成的独特的多芳香族寡肽。体外研究提供了对 albicidin 生物合成机制的进一步了解。这些发现将使albicidin的抑制机制的结构研究及其作为高效抗菌药物的评估成为可能。
Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.