Multimodal adaptive optics retinal imager: design and performance.
Multimodal adaptive optics retinal imager: design and performance.
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DOI：
10.1364/josaa.29.002598
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发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Fulton AB
中科院分区：
文献类型：
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作者：
Hammer DX;Ferguson RD;Mujat M;Patel A;Plumb E;Iftimia N;Chui TY;Akula JD;Fulton AB
光学相干断层扫描（OCT）和扫描激光检眼镜检查（SLO）是互补的成像方式，两者的结合可以为临床医生提供大量信息，以检测视网膜疾病，监测疾病进展或评估新疗法。自适应光学（AO）是一种能够校正来自眼像差的波前畸变的工具。我们已经开发出一种多模态自适应光学系统（MAOS），用于各种研究和临床应用中的高分辨率多功能。该系统将OCT和SLO成像通道集成到AO光路中，光学器件和硬件设计具有特定功能，可同时输出SLO/OCT，用于高保真AO校正，用于人类，灵长类动物和小动物，以及有效定位和定向视网膜感兴趣区域。MAOS系统在人类受试者和啮齿动物身上进行了测试。介绍并讨论了人体和动物研究的设计、性能表征和初始代表性结果。
Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are complementary imaging modalities, the combination of which can provide clinicians with a wealth of information to detect retinal diseases, monitor disease progression, or assess new therapies. Adaptive optics (AO) is a tool that enables correction of wavefront distortions from ocular aberrations. We have developed a multimodal adaptive optics system (MAOS) for high resolution multifunctional use in a variety of research and clinical applications. The system integrates both OCT and SLO imaging channels into an AO beam path. The optics and hardware were designed with specific features for simultaneous SLO/OCT output, for high fidelity AO correction, for use in humans, primates, and small animals, and for efficient location and orientation of retinal regions-of-interest. The MAOS system was tested on human subjects and rodents. The design, performance characterization, and initial representative results from the human and animal studies are presented and discussed.