EFFECTS OF LOW CONCENTRATIONS OF ZINC ON THE GROWTH AND DIMORPHISM OF CANDIDA-ALBICANS - EVIDENCE FOR ZINC-RESISTANT AND ZINC-SENSITIVE PATHWAYS FOR MYCELIUM FORMATION
EFFECTS OF LOW CONCENTRATIONS OF ZINC ON THE GROWTH AND DIMORPHISM OF CANDIDA-ALBICANS - EVIDENCE FOR ZINC-RESISTANT AND ZINC-SENSITIVE PATHWAYS FOR MYCELIUM FORMATION
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DOI：
10.1128/iai.26.1.348-354.1979
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发表时间：
1979-01-01
影响因子：
3.1
通讯作者：
SOLL, DR
中科院分区：
文献类型：
--
作者：
BEDELL, GW;SOLL, DR
研究了低浓度Zn对白色念珠菌生长和二态性的影响。添加到在 25°C 下生长的生长培养物中的微摩尔浓度的 Zn。 C 导致稳定期球体的最终浓度增加 2 倍，导致稳定期出芽周期的异步阻断，完全抑制 2 个独立分离的人类菌株中的菌丝体形成，这些菌株在稳定期产生低但显着水平的菌丝体，并完全抑制突变体 M10 培养物中的菌丝体形成，其中超过 60% 的细胞在稳定期形成菌丝体。微摩尔浓度的 Zn 不会抑制通过将细胞从静止期培养物释放到 37°C 的新鲜培养基中诱导的菌丝体形成。 C. 如果 25°C 初始培养物的生长培养基中存在 Zn。 C，释放到37℃新鲜培养基中后随后菌丝体形成的平均时间。 C减半。上述效果是锌所特有的。提出了菌丝体形成的替代途径的可能性，并讨论了医学意义。
The effects of low concentrations of Zn on the growth and dimorphism of C. albicans were studied. Micromolar concentrations of Zn added to growth cultures grown at 25.degree. C cause a 2-fold increase in the final concentration of spheres at stationary phase, result in an asynchronous block in the budding cycle at stationary phase, completely suppress mycelium formation in 2 independently isolated human strains which produce low but significant levels of mycelia at stationary phase and completely suppress mycelium formation in cultures of mutant M10, in which over 60% of the cells form mycelia at stationary phase. Micromolar concentrations of Zn do not inhibit mycelium formation induced by releasing cells from stationary-phase cultures into fresh medium at 37.degree. C. If Zn is present in the growth medium of the initial culture at 25.degree. C, the average time of subsequent mycelium formation after release into fresh medium at 37.degree. C is halved. The above effects are specific to Zn. The possibility of alternate pathways for mycelium formation is suggested and medical implications are discussed.