Detection of PERK Signaling in the Central Nervous System.
Detection of PERK Signaling in the Central Nervous System.
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中枢神经系统中 PERK 信号传导的检测。
DOI：
10.1007/978-1-0716-1732-8_15
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lin,Wensheng
中科院分区：
文献类型：
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作者：
Lei,Zhixin;Stone,Sarrabeth;Lin,Wensheng
响应内质网 (ER) 应激，胰腺 ER 激酶 (PERK) 信号传导的激活通过磷酸化真核翻译起始因子 2α (eIF2α) 使细胞适应应激条件。 eIF2α 的磷酸化会抑制整体蛋白质翻译，但会通过诱导转录因子 ATF4 来刺激众多应激反应基因的表达。大量研究表明，PERK信号的激活对中枢神经系统（CNS）的各种疾病有有益或有害的影响，包括神经退行性疾病、髓鞘质疾病、CNS损伤等。本章致力于描述中枢神经系统疾病中 PERK 信号传导检测的实用方法。
In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) signaling adapts cells to stressful conditions by phosphorylating eukaryotic translation initiation factor 2α (eIF2α). Phosphorylation of eIF2α inhibits global protein translation but stimulates the expression of numerous stress-responsive genes by inducing the transcription factor ATF4. A large number of studies have shown that activation of PERK signaling has beneficial or detrimental effects in various diseases of the central nervous system (CNS), including neurodegenerative diseases, myelin disorders, CNS injuries, among others. This chapter is devoted to describing the practical methods for the detection of PERK signaling in CNS diseases.