The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy
The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy
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DOI：
10.1016/j.ajo.2004.08.037
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发表时间：
2005-01-01
影响因子：
4.2
通讯作者：
Manea, M
中科院分区：
文献类型：
--
作者：
Piccolino, FC;De La Longrais, RR;Manea, M
目的：利用光学相干断层扫描（OCT）描述中心性浆液性脉络膜视网膜病变（CSC）中黄斑中心凹光感受器层的变化，并评估其与视力（VA）丧失的相关性。
设计：观察性病例系列。
方法：我们使用高分辨率OCT研究了28只患有急性或慢性CSC的眼睛。将黄斑中心凹脱离的光感受器层的断层扫描结果与视力进行比较。对16只黄斑中心凹重新附着后的眼睛也进行了评估。
结果：14只眼睛黄斑中心凹脱离处的外光感受器层（OPL）得以保留，其中13只眼睛症状持续1年。保留的OPL在7只眼睛中呈均匀轮廓，在7只眼睛中呈颗粒状轮廓。OPL保留的眼睛平均视力为0.19 logMAR，OPL萎缩的眼睛平均视力为0.72 logMAR（P < 0.001）。在脱离消退后观察的病例包括6只OPL均匀保留的眼睛、5只OPL颗粒状保留的眼睛和5只OPL萎缩的眼睛。OPL保留的眼睛最终平均视力为0.06 logMAR，OPL萎缩的眼睛最终平均视力为0.90 logMAR（P < 0.001）。OPL保留的眼睛中73%视力提高，而OPL萎缩的眼睛中无视力提高（P = 0.025）。OPL均匀保留的眼睛中83%视力完全恢复，而OPL颗粒状保留的眼睛中无视力完全恢复（P = 0.015）。
结论：高分辨率OCT显示CSC中黄斑中心凹光感受器层的变化与视力丧失高度相关，并可预测黄斑重新附着后的视力恢复。（C）2005年，爱思唯尔公司版权所有。
PURPOSE: To describe changes of the foveal photoreceptor layer using optical coherence tomography (OCT) in central serous chorioretinopathy (CSC) and evaluate the correlation with visual acuity (VA) loss.DESIGN: Observational case series.METHODS: We studied 28 eyes with acute or chronic CSC using high-resolution OCT. The tomographic findings of the detached foveal photoreceptor layer were compared with VA. Sixteen eyes also were evaluated after foveal reattachment.RESULTS: The outer photoreceptor layer (OPL) in the detached fovea was preserved in 14 eyes, of which 13 had symptoms for 1 year. The preserved OPL had an even profile in 7 eyes and a granulated profile in 7 eyes. Mean VA was 0.19 logMAR with a preserved OPL and 0.72 logMAR with an atrophic OPL (P < .001). Cases seen after the detachment resolved included 6 eyes with preserved even OPL, 5 eyes with preserved granulated OPL, and 5 eyes with atrophic OPL. Mean final VA was 0.06 logMAR in eyes with preserved OPL and 0.90 logMAR in eyes with atrophic OPL (P < .001). The VA improved in 73% of eyes with preserved OPL and no eyes with atrophic OPL (P = .025). The VA recovered completely in 83% of eyes with preserved even OPL and no eyes with preserved granulated OPL (P = .015).CONCLUSION: High-resolution OCT demonstrates changes in the foveal photoreceptor layer in CSC that highly correlate with VA loss and may predict visual recovery after macular reattachment. (C) 2005 by Elsevier Inc. All rights reserved.