CELL-LINE SEGREGATION DURING PERIPHERAL NERVOUS-SYSTEM ONTOGENY
CELL-LINE SEGREGATION DURING PERIPHERAL NERVOUS-SYSTEM ONTOGENY
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DOI：
10.1126/science.3952494
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发表时间：
1986-03-28
期刊：
影响因子：
56.9
通讯作者：
LEDOUARIN, NM
中科院分区：
文献类型：
--
作者：
LEDOUARIN, NM
脊椎动物的周围神经系统起源于神经嵴和外胚层基板。鹌鹑雏嵌合体的构建提供了有关神经嵴和基板细胞的迁移和命运的重要信息。将神经嵴组织移植到这些嵌合体的不同部位已经证明，神经嵴细胞的分化在其迁移过程中，特别是在神经节形成过程中，受到环境影响的控制。体外和单克隆抗体技术的实验表明，这些环境因素作用于异质的神经嵴细胞群体，其发育潜能部分受限于明确的分化途径。
The peripheral nervous system of vertebrates arises from the neural crest and the ectodermal placodes. Construction of quail-chick chimaeras has provided significant information on the migration and fate of the neural crest and placodal cells. Transplantation of neural crest tissue to various sites in these chimaeras has demonstrated that the differentiation of neural crest cells is controlled by environmental influences during their migration and, particularly, during gangliogenesis. Experiments with in vitro and monoclonal antibody techniques have shown that these environmental cues act on a heterogeneous population of neural crest cells whose developmental potencies are partly restricted to definite differentiation pathways.