OVARIAN CLEAR CELL-CARCINOMA - A CLINICOPATHOLOGIC ANALYSIS OF 44 CASES
OVARIAN CLEAR CELL-CARCINOMA - A CLINICOPATHOLOGIC ANALYSIS OF 44 CASES
复制标题
DOI：
10.1097/00004347-198906000-00001
复制
发表时间：
1989-06-01
影响因子：
2.4
通讯作者：
KNAPP, RC
中科院分区：
文献类型：
--
作者：
MONTAG, AG;JENISON, EL;KNAPP, RC
报告44例卵巢纯透明细胞癌的临床表现和病理结果。患者年龄范围为28至78岁（平均50.6岁）; 54%为未经产。33%的患者在受累的卵巢有子宫内膜异位症，另外25%的患者仅在远离肿瘤的部位有子宫内膜异位症。显微镜下，观察到三种结构模式（乳头状、管状和实体）和四种细胞类型（透明、鞋钉、嗜酸性和扁平）。占优势的管状囊性结构模式是一个良好的预后因素（p < 0.01），然而，不同细胞类型的生存率没有显著差异，传统的结构和细胞学标准对肿瘤的分级对生存率没有预测价值。临床分期是最重要的预后因素（p < 0.001），5年总生存率为34%，I期生存率为55%。较差的I期存活反映了研究中的15名患者（34%）具有Iaii期病变。在25例复发的患者中，远处器官受累（40%）和淋巴结受累（40%）都很常见。卵巢透明细胞癌具有独特的病理和临床特征，是一种独特的组织学类型。
The clinical aspects and pathologic findings in 44 cases of pure clear cell carcinoma of the ovary are presented. The patients ranged in age from 28 to 78 years (mean, 50.6 years); 54% were nulliparous. Thirty-three percent of the patients had endometriosis in the involved ovary, and an additional 25% had endometriosis only in sites distant from the tumor. Microscopically, three architectural patterns (papillary, tubulocystic, and solid) and four cell types (clear, hobnail, eosinophilic, and flattened) were seen. A predominant tubulocystic architectural pattern was a good prognostic factor (p < 0.01); however, no significant difference in survival by cell type was found. Grading of the tumors by conventional architectural and cytologic criteria had no predictive value for survival. Stage at presentation was the most important prognostic factor (p < 0.001), with a 5-year overall survival of 34% and stage I survival of 55%. The poor stage I survival reflects the 15 patients (34%) in the study with stage Iaii lesions. In the 25 patients who developed recurrence, both distant organ involvement (40%) and lymph node involvement (40%) were frequent. Ovarian clear cell carcinoma has unusual pathologic and clinical features, and it represents a distinct histologic type of ovarian carcinoma.