Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance
Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance
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DOI：
10.1038/hr.2012.197
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发表时间：
2013-05-01
影响因子：
5.4
通讯作者：
Otsuji, Yutaka
中科院分区：
文献类型：
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作者：
Kamezaki, Fumihiko;Sonoda, Shinjo;Otsuji, Yutaka
这项研究的目的是检验代谢综合征(METS)患病率的季节性变化与胰岛素抵抗增加有关的假设。在2010年6月(夏季)接受胰岛素抵抗稳态模型评估(HOMA-IR)的840名日本男性工作者中，我们前瞻性地研究了2010年12月(冬季)接受评估的758名受试者(年龄40-65岁)。METS的定义是根据国际糖尿病联合会(IDF)和日本内科学会(JSIM)提出的标准。研究对象的HOMA-IR中位数为0.84(四分位数范围：0.60-1.19)。IDF和JSIM-Mets的患病率分别由夏季的12.4%和9.6%上升到冬季的16.6%和13.3%(P
The aim of this study was to examine the hypothesis that seasonal variation in the prevalence of metabolic syndrome (MetS) is associated with increased insulin resistance. Among 840 Japanese male workers who were evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR) in June (summer) 2010, we prospectively studied a total of 758 subjects (40-65 years of age) who underwent an assessment in December (winter) 2010. MetS was defined according to the criteria proposed by the International Diabetes Federation (IDF) and the Japanese Society of Internal Medicine (JSIM). The median level of HOMA-IR in the study subjects was 0.84 (interquartile range: 0.60-1.19). The prevalence rates of IDF- and JSIM-MetS significantly increased from 12.4 and 9.6% in the summer to 16.6 and 13.3% in the winter, respectively (each P