Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics.
Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics.
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DOI：
10.3389/fimmu.2014.00682
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发表时间：
2014
影响因子：
7.3
通讯作者：
Andersen JT
中科院分区：
文献类型：
--
作者：
Sand KM;Bern M;Nilsen J;Noordzij HT;Sandlie I;Andersen JT
新生儿Fc受体（FcRn）首先被发现负责将免疫球蛋白G （IgG）类抗体从母亲转运到胎儿或新生儿，并保护IgG免受细胞内分解代谢。然而，由于FcRn在许多不同的细胞类型和器官中在不同的身体部位表达，现在很明显，相同的受体也可以结合白蛋白，并在IgG和白蛋白的稳态调节中发挥基本作用。因此，为了全面了解每种配体的生物学功能及其在体内的分布，有必要深入表征FcRn如何结合并调节这两种配体的运输。重要的是，随着IgG和白蛋白越来越多地用于治疗，这些知识也与开发新药有关。这篇综述讨论了我们目前对FcRn及其配体之间关系的结构和生物学理解，特别关注白蛋白和基于白蛋白的治疗方法的设计。
The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism. However, it has now become apparent that the same receptor also binds albumin and plays a fundamental role in homeostatic regulation of both IgG and albumin, as FcRn is expressed in many different cell types and organs at diverse body sites. Thus, to gain a complete understanding of the biological function of each ligand, and also their distribution in the body, an in-depth characterization of how FcRn binds and regulates the transport of both ligands is necessary. Importantly, such knowledge is also relevant when developing new drugs, as IgG and albumin are increasingly utilized in therapy. This review discusses our current structural and biological understanding of the relationship between FcRn and its ligands, with a particular focus on albumin and design of albumin-based therapeutics.