Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.
Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.
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在没有其他 T 细胞的情况下，重复的寄生虫感染会诱导 B 细胞的 γ δ T 细胞帮助。
DOI：
10.1016/s0960-9822(02)70718-5
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hayday,AC
中科院分区：
文献类型：
--
作者：
Pao,W;Wen,L;Smith,AL;Gulbranson-Judge,A;Zheng,B;Kelsoe,G;MacLennan,IC;Owen,MJ;Hayday,AC
背景：γδT细胞和αβT细胞一样，是所有已被充分研究的脊椎动物免疫系统的组成部分。然而，γδT细胞对免疫反应的贡献还没有得到很好的描述。特别是，γδ细胞是否能独立于其他T细胞帮助B细胞产生免疫球蛋白并形成生发中心，这是T细胞-B细胞协同作用的解剖焦点，目前尚无定论。结果TCRβ−/−小鼠缺乏除γδT细胞外的所有T细胞，其抗体水平通常高于完全T细胞缺陷小鼠。反复寄生感染TCRβ−/−小鼠，但不是T细胞缺陷小鼠，可提高抗体水平，并诱导包含B细胞和单克隆性γδ细胞的生发中心紧密并列。然而，抗体特异性更常见的是针对自身，而不是针对具有挑战性的病原体。结论在不存在其他T细胞的情况下，反复感染可显著增强γδT细胞-B细胞的协同作用。结论β−/−小鼠反复接种分枝杆菌抗原后，γδT细胞-B细胞协同作用明显增强。然而，缺乏对具有挑战性的病原体的抗体的明显浓缩，从而区分了在类似情况下诱导的γδT细胞帮助和αβT细胞帮助。全身性抗体产生的增加可能与自身免疫的发展特别相关，自身免疫通常发生在患有αβT细胞缺陷的患者，如艾滋病。
Backgroundγδ T cells, likeαβT cells, are components of all well-studied vertebrate immune systems. Yet, the contribution of γδ T cells to immune responses is poorly characterized. In particular, it has not been resolved whether γδ cells, independent of any other T cells, can help B cells produce immunoglobulin and form germinal centers, anatomical foci of specialized T cell–B cell collaboration.ResultsTCRβ−/−mice, which lack all T cells except γδ T cells, routinely displayed higher levels of antibody than fully T cell-deficient mice. Repeated parasitic infection of TCRβ−/−mice, but not of T cell-deficient mice, increased antibody levels and induced germinal centers that contained B cells and monoclonal γδ cells in close juxtaposition. However, antibody specificities were more commonly against self than against the challenging pathogen. γδ T cell–B cell help was not induced by repeated inoculation of TCRβ−/−mice with mycobacterial antigens.ConclusionsIn the absence of any other T cells, γδ T cell–B cell collaboration can be significantly enhanced by repeated infection. However, the lack of obvious enrichment for antibodies against the challenging pathogen distinguishes γδ T cell help fromαβT cell help induced under analogous circumstances. The increased production of generalized antibodies may be particularly relevant to the development of autoimmunity, which commonly occurs in patients suffering fromαβT cell deficiencies, such as AIDS.