Towards understanding the roles of position and geometry on cell fate decisions during preimplantation development.
Towards understanding the roles of position and geometry on cell fate decisions during preimplantation development.
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DOI：
10.1016/j.semcdb.2015.09.006
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发表时间：
2015-12
影响因子：
7.3
通讯作者：
Srinivas S
中科院分区：
文献类型：
--
作者：
Biggins JS;Royer C;Watanabe T;Srinivas S
小鼠胚胎中的第一个谱系分离事件产生两个独立的细胞群：内细胞团和滋养外胚层。据了解，这是由细胞感知它们在胚胎中的位置并相应地分化而引起的。这一过程的细胞和分子基础仍在研究中，并被认为是完全随机的或交替的，受受精时或受精前的某些倾向的影响。在这里，我们认为这些观点在最近的出版物，讨论细胞的几何形状和机械力在这个过程中可能发挥的作用，并描述如何建模可以有助于解决这个问题。
The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under investigation and have variously been considered to be completely stochastic or alternately, subject to some predisposition set up at fertilisation or before. Here, we consider these views in light of recent publications, discuss the possible role of cell geometry and mechanical forces in this process and describe how modelling could contribute in addressing this issue.