The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?
The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?
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DOI：
10.1016/j.tcb.2003.12.008
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发表时间：
2004-02-01
影响因子：
19
通讯作者：
Novick, P
中科院分区：
文献类型：
--
作者：
Guo, W;Novick, P
易位子负责蛋白质穿过内质网膜进入内质网腔，而外囊作用于分泌途径的另一端，将分泌囊泡拴系到胞吐位点。在这里，我们讨论了三个独立的证据，表明令人惊讶的遗传，物理和功能的两个复合物之间的相互作用。虽然现有的证据是相当初步的性质，这些相互作用可能有助于协调细胞的生物合成能力与分泌机制的功能。
The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicate surprising genetic, physical and functional interactions between the two complexes. Although much of the existing evidence is rather preliminary in nature, these interactions might serve to coordinate the biosynthetic capacity of the cell with the function of the secretory machinery.