The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone
The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone
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DOI：
10.1152/ajplegacy.1924.69.3.577
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发表时间：
1924-08-01
影响因子：
--
通讯作者：
Doisy, EA
中科院分区：
文献类型：
--
作者：
Allen, E;Doisy, EA
雌性哺乳动物的性成熟取决于卵巢的内分泌功能，但尚未清楚地证明这是由于性腺的哪一部分。在最近的一篇综述中，Marshall(1)写道：“目前尚不清楚卵巢中究竟是什么因素导致了这种激素的产生，这种激素对女性器官和特征的发育具有兴奋作用，也可能抑制男性器官和特征的发育，....”尽管未成熟卵巢的生理机制尚不清楚，但已经确定的是，第一次排卵通常不会发生在青春期(2)。因此，在此之前没有卵泡，也没有完全成熟，在未成熟的卵巢中通常没有体。因此，卵泡和性趣组织是仅有的两种可能的激素来源，这两种激素导致雌性动物的性成熟状况。卵巢间质组织，作为一个笼统的术语，暗示着可能的内分泌功能，还没有确定的组织学基础。一些研究人员未能在几种哺乳动物的卵巢中发现相当数量的这种物质。然而，施泰因纳奇(3)特别强调它是一种产生激素的来源，这种激素使女性性成熟。Marshall（第346页）总结了t&s的概念：
The attainment of sexual maturity of the female mammal depends upon the endocrine function of the ovary but it has not been clearly demonstrated to which part of the gonad this is due. In a recent review Marshall(1) writes “It is not known what precise ovarian elements are responsible for the production of the hormone which is an excitant for the development of the female organs and characters or the possible inhibition of the distinctively male ones,....” Although the physiology of the immature ovary is still quite obscure, Y it is well established that the first ovulation does not usually occur unt, il puberty(2). Consequently no follicles att, ain to full maturity until that time, and there are normally no corpora lut, ea present in the immature ovary. Therefore the follicles and interst’itial tissue are the only two possible sources of the hormone which brings about a sexually ma, ture condition in the fernale.Ovarian interstitial tissue, used as a general term implying a possible endocrine function, is not yet on a firm histological ba&. Several investigaltors have failed to find it in appreciable amounts in mammalian ovaries of several species. It has, however, been especially stressed bv Steinach (3) as a source of production of the hormone which brings aboui sexual maturity in the female. Marshall (p. 346) summarizes t&is conception: