Goblet cells and mucins: role in innate defense in enteric infections.
Goblet cells and mucins: role in innate defense in enteric infections.
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DOI：
10.3390/pathogens2010055
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发表时间：
2013-02-04
期刊：
影响因子：
--
通讯作者：
Khan WI
中科院分区：
文献类型：
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作者：
Kim JJ;Khan WI
杯状细胞遍布胃肠道，通过合成和分泌高分子量的糖蛋白，即粘蛋白，负责产生和保存保护性粘液毯。黏液层作为一种动态保护屏障的概念是由以下研究提出的：胃肠道炎症条件下黏液蛋白的变化，无菌动物杯状细胞反应的改变，以及对感染的反应中黏液分泌的增强。覆盖在胃肠道上皮上的含有黏液的黏液层是先天宿主防御的前线。黏液蛋白可能是入侵病原体在细胞表面与之相互作用的第一个分子，因此可以限制与其他糖蛋白的结合并中和病原体。本文将重点介绍各种胃肠道感染中杯状细胞反应的已知情况，以及在肠道损伤反应中介导杯状细胞功能和粘蛋白产生的调节网络。此外，我们描述了目前的知识粘蛋白在肠道先天防御的作用。这篇综述的目的是为读者提供杯状细胞生物学的最新进展和目前对黏蛋白在肠道感染中宿主防御中的作用的理解。
Goblet cells reside throughout the gastrointestinal (GI) tract and are responsible for the production and preservation of a protective mucus blanket by synthesizing and secreting high molecular weight glycoproteins known as mucins. The concept of the mucus layer functioning as a dynamic protective barrier is suggested by studies showing changes in mucins in inflammatory conditions of the GI tract, by the altered goblet cell response in germ-free animals, and by the enhanced mucus secretion seen in response to infections. The mucin-containing mucus layer coating the GI epithelium is the front line of innate host defense. Mucins are likely to be the first molecules that invading pathogens interact with at the cell surface and thus, can limit binding to other glycoproteins and neutralize the pathogen. This review will focus on what is known about goblet cell response in various GI infections and the regulatory networks that mediate goblet cell function and mucin production in response to intestinal insults. In addition, we describe the current knowledge on the role of mucins in intestinal innate defense. It is the aim of this review to provide the readers with an update on goblet cell biology and current understanding on the role of mucins in host defense in enteric infections.