LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
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DOI：
10.1152/physrev.00033.2007
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发表时间：
2008-07
影响因子：
33.6
通讯作者：
Strickland DK
中科院分区：
文献类型：
--
作者：
Lillis AP;Van Duyn LB;Murphy-Ullrich JE;Strickland DK
低密度脂蛋白(低密度脂蛋白)受体相关蛋白(最初称为LRP，但现在称为LRP1)是一种广泛表达于多种组织中的大型内源性受体。LRP1是低密度脂蛋白受体家族的一员，在脂蛋白代谢、蛋白酶降解、溶酶体酶激活以及细菌毒素和病毒进入细胞等多种生物学过程中发挥着不同的作用。LRP1基因的缺失会导致小鼠死亡，这揭示了LRP1基因在发育过程中的关键作用，但目前尚不明确。组织特异性基因缺失研究表明，LRP1在血管系统、中枢神经系统、巨噬细胞和脂肪细胞中具有重要作用。LRP1的三个重要性质决定了它在生理上的不同作用：第一，它能够识别30多种不同的配体；第二，它能够通过位于细胞质结构域上的决定簇以一种磷酸化的方式结合大量的细胞质接头蛋白；第三，它能够与其他跨膜受体如整合素和受体酪氨酸激酶的活性相结合并调节其活性。
The low-density lipoprotein (LDL) receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes and cellular entry of bacterial toxins and viruses. Deletion of the LRP1 gene leads to lethality in mice, revealing a critical, but as of yet, undefined role in development. Tissue-specific gene deletion studies reveal an important contribution of LRP1 in the vasculature, central nervous system, in macrophages and in adipocytes. Three important properties of LRP1 dictate its diverse role in physiology: first, its ability to recognize more than thirty distinct ligands; second, its ability to bind a large number of cytoplasmic adaptor proteins via determinants located on its cytoplasmic domain in a phosphorylation-specific manner; and third, its ability to associate with and modulate the activity of other transmembrane receptors such as integrins and receptor tyrosine kinases.
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影响因子：
3.7
作者：
Boucher, Philippe;Li, Wei-Ping;Matz, Rachel L.;Takayama, Yoshiharu;Auwerx, Johan;Anderson, Richard G. W.;Herz, Joachim
通讯作者：
Herz, Joachim
影响因子：
15.9
作者：
Bornstein, P
通讯作者：
Bornstein, P
影响因子：
20.3
作者：
Bovenschen, N;Herz, J;van Viijmen, BJM
通讯作者：
van Viijmen, BJM
影响因子：
32.4
作者：
Basu, S;Binder, RJ;Srivastava, PK
通讯作者：
Srivastava, PK
影响因子：
4.4
作者：
Berwin, B;Hart, JP;Nicchitta, CV
通讯作者：
Nicchitta, CV