Necessity of meningococcal γ-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
Necessity of meningococcal γ-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
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DOI：
10.1128/jb.186.1.244-247.2004
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Watanabe, H
中科院分区：
文献类型：
--
作者：
Takahashi, H;Hirose, K;Watanabe, H
缺乏γ -谷氨酰氨基肽酶（GGT）的脑膜炎奈瑟菌在大鼠脑脊液（CSF）和人工合成的模拟CSF培养基中的生长速度比亲本菌株慢得多，半胱氨酸的加入抑制了生长失败。这些结果表明，在半胱氨酸短缺的环境下，脑膜炎球菌GGT通过从环境γ -谷氨酰半胱氨酸肽中供应半胱氨酸，为脑膜炎球菌增殖提供了优势。
The growth of a gamma-glutamyl aminopeptidase (GGT)-deficient Neisseria meningitidis strain was much slower than that of the parent strain in rat cerebrospinal fluid (CSF) and in a synthetic CSF-mimicking medium, and the growth failure was suppressed by the addition of cysteine. These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental gamma-glutamyl-cysteinyl peptides.