Whole-genome analysis and description of an outbreak due to carbapenem-resistant Ochrobactrum anthropi causing pseudo-bacteraemias.
Whole-genome analysis and description of an outbreak due to carbapenem-resistant Ochrobactrum anthropi causing pseudo-bacteraemias.
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全基因组分析和描述由耐碳青霉烯类人苍白杆菌引起的假菌血症引起的暴发。
DOI：
10.1016/j.nmni.2018.09.002
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发表时间：
2018
影响因子：
4
通讯作者：
Almuzara,M
中科院分区：
文献类型：
--
作者：
Montaña,S;Fernandez,JS;Barenboim,M;Hernandez,M;Kayriyama,C;Carulla,M;Iriarte,A;Ramirez,MS;Almuzara,M
人苍白杆菌是一种罕见的人类病原体，主要从导管相关性菌血症患者中分离出来，很少从其他感染中分离出来。2016年，从阿根廷一家医院回收了6例由碳青霉烯类耐药人源性分离株引起的假菌血症病例。分离株暴露的耐药表型引起了我们的注意，并导致了广泛的流行病学调查。在这里，我们描述了碳青霉烯类耐药O. anthropi爆发的特点，其可能的原因是受污染的收集管。一个菌株的基因组分析揭示了各种耐药决定簇的存在。近年来，临床环境中罕见的多重耐药病原体的恢复有所增加，因此强调需要实施标准化的感染控制实践和流行病学调查，以确定医院暴发的真实的原因。
Ochrobactrum anthropi,a rare human pathogen, has been isolated predominantly from patients with catheter-related bacteraemia and rarely from other infections. In 2016, six cases of pseudo-bacteraemia caused by carbapenem-resistantO. anthropiisolates were recovered from an Argentinian hospital. The resistant phenotype exposed by the isolates caught our attention and led to an extensive epidemiologic investigation. Here we describe the characterization of a carbapenem-resistantO. anthropioutbreak whose probable cause was by contaminated collection tubes. The genome analysis of one strain revealed the presence of various resistant determinants. Among them, a metal-dependent hydrolase of the β-lactamase superfamily I,phnP,was found. Lately the recovery of unusual multidrug-resistant pathogens in the clinical setting has increased, thus emphasizing the need to implement standardized infection control practice and epidemiologic investigation to identify the real cause of hospital outbreaks.