Vitamin D and barrier function:: a novel role for extra-renal 1α-hydroxylase
Vitamin D and barrier function:: a novel role for extra-renal 1α-hydroxylase
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DOI：
10.1016/j.mce.2003.11.017
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发表时间：
2004-02-27
影响因子：
4.1
通讯作者：
Adams, JS
中科院分区：
文献类型：
--
作者：
Hewison, M;Zehnder, D;Adams, JS
Much recent attention has focused on the positive health benefits of vitamin D beyond its established role in calcium homeostasis. Epidetmology has highlighted the link between vitamin D deficiency and prevalent diseases such as common cancers and autoimmune disease. Furthermore, studies in vitro have shown that the active form of vitamin D, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) is a potent antiproliferative and itnmunosuppressive agent. The net effect of this has been the generation and analysis of synthetic analogues of vitamin D for potential use in the treatment of cancers and other disorders including psoriasis. However, there is increasing interest in the impact that vitamin D may have on normal physiology above and beyond its classical effects on calcium homeostasis and bone metabolism. We have postulated that these `non-calcetnic' effects of vitamin D are dependent on extra-renal synthesis of 1,25(OH)2D3 via the enzyme la-hydroxylase at barrier sites throughout the body. Here we present a review of the mechanisms associated with extra-renal 1 a-hydroxylase, and we also speculate on how this `new' physiological role for vitamin D may actually reflect an ancient function for this pluripotent secosteroid. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
