Risks for frequent antimicrobial-treated infections in postmenopausal women.
Risks for frequent antimicrobial-treated infections in postmenopausal women.
复制标题
绝经后妇女频繁接受抗菌药物治疗感染的风险。
DOI：
10.1007/bf03324474
复制
发表时间：
2003
影响因子：
4
通讯作者：
LaCroix,AndreaZ
中科院分区：
文献类型：
--
作者：
Boudreau,DeniseM;Leveille,SuzanneG;Gray,ShellyL;Black,DouglasJ;Guralnik,JackM;Ferrucci,Luigi;LaCroix,AndreaZ
背景和目的：感染是老年人发病和死亡的主要原因。人们对改变老年人感染易感性的因素知之甚少。这项针对绝经后妇女的研究检查了可能增加频繁感染风险的健康相关状况和行为因素，定义为平均每年有一次或多次感染。方法：对1320名55 ~ 80岁女性进行5年随访的前瞻性队列研究。研究对象是普吉特海湾（Puget Sound）团体健康合作组织（GHC）的参与者，他们参加了一项大型骨折预防试验，并参与了饮食和补充维生素使用的调查。主要结果，每位受试者感染事件总数，来源于一种基于GHC自动药房记录中记录的抗菌药物处方填充识别门诊感染的新方法。结果：在随访期间，常见肺部疾病（OR=6.1, 95% CI 2.8-13.4）、服用维生素C处方（OR=2.1, 95% CI 1.4-3.4）以及慢性疾病评分的第二和第三分位数（OR=1.7, 95% CI 1.1-2.7和OR=2.4, 95% CI 1.5-3.9）与5种或更多抗微生物药物治疗感染相关。体重指数（BMI）小于22 kg/m2（OR=0.6, 95% CI 0.3-1.0）提示存在相关性。结论：该研究为门诊感染的危险因素提供了新的信息，并提出了老年妇女对频繁感染的易感性的新问题。此外，本研究中使用的自动药房记录方法为未来的流行病学研究提供了一种低成本的替代方法。
Background and aims:Infections are a major cause of morbidity and mortality in older adults. Little is known about factors that alter the susceptibility to infection in the older population. This study in postmenopausal women examines health-related conditions and behavioral factors that may increase the risk of frequent infections, defined as having, on average, one or more infections per year.Methods:A prospective cohort study with 5 years of follow-up was conducted in 1320 women aged 55 to 80 years. The subjects were Group Health Cooperative of Puget Sound (GHC) enrollees screened for a large fracture prevention trial who also participated in a survey of dietary and supplemental vitamin use. The main outcome, total number of infection events per subject, was derived from a new method of identifying outpatient infections based on the antimicrobial prescription fills recorded in GHC automated pharmacy records.Results:Prevalent lung disease (OR=6.1, 95% CI 2.8–13.4), receiving a prescription for vitamin C (OR=2.1, 95% CI 1.4–3.4), and the second and third tertiles of the Chronic Disease Score (OR=1.7, 95% CI 1.1-2.7 and OR=2.4, 95% CI 1.5–3.9, respectively) were associated with 5 or more antimicrobial-treated infections during follow-up. A body mass index (BMI) of less than 22 kg/m2(OR=0.6, 95% CI 0.3–1.0) was suggestive of an association.Conclusions:The study provides new information on risk factors for outpatient infections and raises new questions regarding the susceptibility to frequent infections in older women. In addition, the automated pharmacy record method used in this study offers a low-cost alternative for use in future epidemiologic research.