Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Uric Acid in Japanese Individuals
Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Uric Acid in Japanese Individuals
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DOI：
10.3899/jrheum.090736
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Nagai, Ryozo
中科院分区：
文献类型：
--
作者：
Ishizaka, Nobukazu;Ishizaka, Yuko;Nagai, Ryozo
Objective.研究表明，肥胖与血清尿酸增加有关：关于肥胖指标变化与尿酸浓度变化之间关系的数据很少。我们研究了腰围百分比变化（%dWC）之间的关系。体重指数（%dBMI）和血清尿酸（%dUA）。3153人[男性1968人，女性1185人（绝经前536人）。649例绝经后妇女），在2年内进行一般健康筛查，未服用抗高尿酸血症药物。多元逐步回归分析显示，绝经后妇女和男子的%dBMI与%dUA呈正相关。在校正血压和肾功能变化后，这种关联仍具有统计学意义。在绝经前妇女中，%dBMI和%dUA之间的相关性不显著。在男性中，%dWC是%dUA的预测因素，尽管当%dBMI用作统计模型中的协变量时，它并不保持显著性。多因素Logistic回归分析显示，绝经后女性最低dBMI四分位数（%dBMI < -1.86）与最低dUA四分位数（%dUA < -7.41）之间的比值比为2.04（95%CI 1.35-3.07），男性为1.46（95%CI 1.14-1.86）。体重减轻可能是降低血清UA水平的所有有效的非医学策略，特别是在绝经后女性和男性中。（2009年12月23日首次发布：J Rheumol 2010;37：410-6：doi：10.3899/jrheum.090736）
Objective. Studies have shown that obesity is associated with an increase in serum uric acid: and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC). body mass index (%dBMI), and serum Uric acid (%dUA).Methods. The data of 3153 individuals [1968 men, 1185 women (536 premenopausal. 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking anti-hyperuricemic medication were analyzed.Results. Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal Women and men. and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI Was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < -1.86) and the lowest %dUA quartile (%dUA < -7.41) was 2.04 (95% CI 1.35-3.07) in postmenopausal women and 1.46 (95% CI 1.14-1.86) in men.Conclusion. Weight loss may represent all effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men. (First Release Dec 23 2009: J Rheumatol 2010;37:410-6: doi: 10.3899/jrheum.090736)